Correlative Factors of Child Lingua Geographica Formation and the Immunological Mechanism

Li Fufeng; Zhuang Yanhong; Wang Yiqin; et al.

doi:10.13288/j.11-2166/r.2006.07.032

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Correlative Factors of Child Lingua Geographica Formation and the Immunological Mechanism

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- Correlative Factors of Child Lingua Geographica Formation and the Immunological Mechanism
- Journal of Traditional Chinese Medicine Issue 7, Pages: 531-534(2006)
- 作者机构：
  
  1. 上海中医药大学教学实验中心综合实验教研室
  2. 上海中医药大学教学实验中心综合实验教研室上海市蔡伦路1200号,201203
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2006.07.032
  CLC： R272
- Published：2006
- 稿件说明：
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[1]李福凤,庄燕鸿,王忆勤,李果刚,燕海霞,王惠芳.小儿花剥苔形成的相关因素及其免疫学机制[J].中医杂志,2006(07):531-534.

Li Fufeng, Zhuang Yanhong, Wang Yiqin, et al. Correlative Factors of Child Lingua Geographica Formation and the Immunological Mechanism[J]. Journal of Traditional Chinese Medicine2006, (7): 531-534.
[1]李福凤,庄燕鸿,王忆勤,李果刚,燕海霞,王惠芳.小儿花剥苔形成的相关因素及其免疫学机制[J].中医杂志,2006(07):531-534. DOI： 10.13288/j.11-2166/r.2006.07.032.

Li Fufeng, Zhuang Yanhong, Wang Yiqin, et al. Correlative Factors of Child Lingua Geographica Formation and the Immunological Mechanism[J]. Journal of Traditional Chinese Medicine2006, (7): 531-534. DOI： 10.13288/j.11-2166/r.2006.07.032.

摘要

目的:探讨小儿花剥苔发生的主要相关因素及其免疫学机制。方法:运用临床流行病学方法调查1562例儿童

同时采用流式细胞术检测T、B淋巴细胞亚群、细胞趋化因子受体-3（CCR3）、细胞趋化因子受体-5（CCR5）表达量等。结果:花剥苔形成的主要因素为过敏、哮喘史、感染、先天体质等。花剥苔组T、B淋巴细胞亚群及CCR3、白细胞介素4水平高于非花剥苔组及正常组（P<0.05）。结论:小儿花剥苔形成与过敏、感染、哮喘史、先天体质密切相关

且T、B淋巴细胞亚群改变为花剥苔形成的免疫学机制提供了客观依据。

Abstract

Objective:To approach to main correlative factors of child lingua geographica formation and the immunological mechanism.Methods:1562 children were surveyed with clinical epidemiological method

and flow cytometry was used to determin T- and B-lymphocyte subgroups and expression of cell chemotactic factor receptor-3（CCR3） and cell chemotoctic factor receptor-5（CCR5）.Results:The main correlative factors of child lingua geographica formation were anaphylaxis

asthma history

infection

congenital constitution.The levels of T- and B-lymphocyte subgroups

CCR3 and interlukin-4 in the lingua geographica group were higher than that in the non-lingua geographica group and the control group（P<0.05）.Conclusion:Formation of child lingua geographica is closely related with anaphylaxis

asthma history

infection and congenital constitution

and the changes of T- and B-lymphocyte subgroups provide an objective basis for immunological mechanisms of child lingua geographica formation.

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