Effects of Buyang Huanwu Decoction and Astragalus Mongholicus on PAF Receptor Activity in Rabbits in Vitro

Yao Hui~1; Zhang Jiping~1; Chen Zhixi~2; et al.

doi:10.13288/j.11-2166/r.2006.08.037

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Effects of Buyang Huanwu Decoction and Astragalus Mongholicus on PAF Receptor Activity in Rabbits in Vitro

更新时间：2021-11-17

- Effects of Buyang Huanwu Decoction and Astragalus Mongholicus on PAF Receptor Activity in Rabbits in Vitro
- Journal of Traditional Chinese Medicine Issue 8, Pages: 613-615(2006)
- 作者机构：
  
  1. 佛山市第二人民医院药剂科、科教科
  2. 广州中医药大学核医学实验室
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2006.08.037
  CLC： R285
- Published：2006
- 稿件说明：
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[1]姚晖,张继平,陈芝喜,李志强.补阳还五汤及黄芪体外对家兔血小板活化因子受体活性的影响[J].中医杂志,2006(08):613-615.

Yao Hui~1, Zhang Jiping~1, Chen Zhixi~2, et al. Effects of Buyang Huanwu Decoction and Astragalus Mongholicus on PAF Receptor Activity in Rabbits in Vitro[J]. Journal of Traditional Chinese Medicine2006, (8): 613-615.
[1]姚晖,张继平,陈芝喜,李志强.补阳还五汤及黄芪体外对家兔血小板活化因子受体活性的影响[J].中医杂志,2006(08):613-615. DOI： 10.13288/j.11-2166/r.2006.08.037.

Yao Hui~1, Zhang Jiping~1, Chen Zhixi~2, et al. Effects of Buyang Huanwu Decoction and Astragalus Mongholicus on PAF Receptor Activity in Rabbits in Vitro[J]. Journal of Traditional Chinese Medicine2006, (8): 613-615. DOI： 10.13288/j.11-2166/r.2006.08.037.

摘要

目的:探讨补阳还五汤及黄芪体外对家兔血小板活化因子（PAF）受体活性的作用

阐明黄芪在该方中的配伍机制。方法:将动物分为补阳还五汤全方组、活血组和补气组

采用放射配基受体结合实验

以家兔血小板PAF受体特异结合抑制率为评价指标

探讨3组体外对家兔血小板PAF受体活性的影响。结果:3组均能抑制3H-PAF与家兔血小板PAF受体的特异结合

对PAF受体特异结合抑制程度由大到小依次为活血组、全方组、补气组

各组之间抑制率差异均有显著性（P<0.01）。结论:单味黄芪（120g）对家兔血小板PAF受体与3H-PAF的特异结合有一定的抑制作用

但黄芪与方中活血药配伍后

能使后者拮抗血小板PAF受体的作用明显减弱

使全方拮抗血小板PAF受体的作用缓和

防止大量活血药攻伐太过

体现了补阳还五汤“祛瘀而不伤正”的配伍机制。

Abstract

Objective:To study the effects of Buyang Huanwu Decoction（BHD） and Astragalus mongholicus on in vitro platelet activating factor（PAF） receptor activity in the platelet of the rabbit.Methods:The study included three groups

whole BHD group

group of activating blood circulation and group of invigorating qi

and the specific binding inhibition rate of PAF receptor was determined with radioligand receptor binding method.Effects on in vitro PAF receptor activity in the platelet of the rabbit were compared among the three groups.Results:The specific binding of

3 H-PAF with PAF receptor in the platelet of the rabbit was inhibited in all the three groups

and the inhibiting degree was in the following order:group of activating blood circulation

whole BHD group

group of invigorating qi with significant differences among the three groups（P

0.01）.Conclusion:Single Astragalus mongholicus（120g） can inhibit the specific binding of PAF receptor in the platelet of the rabbit with

3 H-PAF

but combination of Astragalus mongholicus with the drugs for activating blood circulation in BHD can significantly decrease the inhibiting action of the latter on PAF receptor activity of the platelet

reflecting the combined mechanism of “ removing blood stasis without injuring the votal qi” in BHD.

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