Experimental Study on Concerted Application of Complex Prescription for Reducing the Renal Toxicity of Aristolochia manshuriensis Kom

Li Chunxiang1; Ding Liyu2; Li Guochuan1; et al.

doi:10.13288/j.11-2166/r.2006.09.035

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Experimental Study on Concerted Application of Complex Prescription for Reducing the Renal Toxicity of Aristolochia manshuriensis Kom

更新时间：2021-11-17

- Experimental Study on Concerted Application of Complex Prescription for Reducing the Renal Toxicity of Aristolochia manshuriensis Kom
- Journal of Traditional Chinese Medicine Issue 9, Pages: 694-697(2006)
- 作者机构：
  
  1. 河北医科大学中医学院中药研究室
  2. 河北医科大学药学院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2006.09.035
  CLC： R289
- Published：2006
- 稿件说明：
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[1]李春香,丁里玉,李国川,窦玉红,丁芳,郝蕾.复方配伍减低关木通肾毒性的实验研究[J].中医杂志,2006(09):694-697.

Li Chunxiang1, Ding Liyu2, Li Guochuan1, et al. Experimental Study on Concerted Application of Complex Prescription for Reducing the Renal Toxicity of Aristolochia manshuriensis Kom[J]. Journal of Traditional Chinese Medicine2006, (9): 694-697.
[1]李春香,丁里玉,李国川,窦玉红,丁芳,郝蕾.复方配伍减低关木通肾毒性的实验研究[J].中医杂志,2006(09):694-697. DOI： 10.13288/j.11-2166/r.2006.09.035.

Li Chunxiang1, Ding Liyu2, Li Guochuan1, et al. Experimental Study on Concerted Application of Complex Prescription for Reducing the Renal Toxicity of Aristolochia manshuriensis Kom[J]. Journal of Traditional Chinese Medicine2006, (9): 694-697. DOI： 10.13288/j.11-2166/r.2006.09.035.

摘要

目的:观察含关木通的传统复方导赤散对大鼠的急性、慢性肾损伤

探讨其配伍、剂量、用药时间与关木通肾毒性的相关性。方法:用关木通、导赤散水煎液

分别以关木通每日6g/kg、12g/kg、24g/kg不同剂量给大鼠连续灌胃7天（急毒实验）和每日4g/kg连续灌胃给药12周（慢毒实验）

观察各组大鼠肾功能及肾组织形态学变化;同时采用高效液相方法检测单味关木通药液、导赤散药液及导赤散拆方药液中马兜铃酸A溶出量。结果:关木通各剂量组均有导致大鼠肾功能及肾脏形态学损伤作用

且与剂量、用药时间呈正相关;复方导赤散配伍对大鼠造成的肾功能及肾脏形态学损伤均较单味关木通轻

且随剂量、用药时间的合理调配而肾毒性显著降低。复方导赤散药液中马兜铃酸A溶出量明显低于单味关木通药液组。结论:复方导赤散配伍具有减低关木通肾毒性作用;复方导赤散配伍和/或竹叶分别具有减低关木通中马兜铃酸A溶出量作用。

Abstract

Objective:To observe acute and chronic renal toxicity of the traditional prescription Daochi San containing Aristolochia manshuriensis Kom（GMT） in rats

and to probe into correlativity of concerted application

dose

administration time of the prescription with renal intoxicity of GMT.Methods:The rats were administrated with Decoction of GMT and Daochi San by intragastric infusion.The dosage of GMT is 6g/kg

12g/kg and 24g/kg each day for 7 days （acute toxic experiment）

and 4g/kg each day for 12 weeks（chronic toxic experiment）

respectively.Changes of renal function and morphology of the renal tissue were investigated in all groups;Dissolved amount of aristolochic acid A in the Decoctions of single GMT

Daochi San and separated drugs of Daochi San were detected with high performance liquid chromatography.Results:All different doses of GMT induced injuries of renal function and renal morphology in rats

which were positively correlated with the dose and administration time.Concerted application of compound Daochi San could remit the injury of single GMT on renal function and renal morphology

and the renal toxicity was significantly decreased by rational dose and administration time.The dissolved amount of aristolochic acid A in compound Daochi San Decoction was lower than that in single Decoction.Conclusion:Complex prescription Daochi San can decrease renal toxicity of GMT

and Daochi San and/or bamboo leaves have significant action of decreasing the dissolved amount of aristolochic acid A in GMT.

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