Effect of Yougui Wan on GluT4 mRNA Expression in the Skeletal Muscle of Experimental Hypothyroidism Rats

Jia Xilian1; Xu Cankun2; Zhou Yang3; et al.

doi:10.13288/j.11-2166/r.2006.09.036

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Effect of Yougui Wan on GluT4 mRNA Expression in the Skeletal Muscle of Experimental Hypothyroidism Rats

更新时间：2021-11-17

- Effect of Yougui Wan on GluT4 mRNA Expression in the Skeletal Muscle of Experimental Hypothyroidism Rats
- Journal of Traditional Chinese Medicine Issue 9, Pages: 698-701(2006)
- 作者机构：
  
  1. 天津医科大学总医院中医科
  2. 天津医科大学
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2006.09.036
  CLC： R285
- Published：2006
- 稿件说明：
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[1]贾锡莲,徐灿坤,周阳,曲竹秋.右归丸对实验性甲状腺功能减退大鼠骨骼肌GluT4 mRNA表达水平的影响[J].中医杂志,2006(09):698-701.

Jia Xilian1, Xu Cankun2, Zhou Yang3, et al. Effect of Yougui Wan on GluT4 mRNA Expression in the Skeletal Muscle of Experimental Hypothyroidism Rats[J]. Journal of Traditional Chinese Medicine2006, (9): 698-701.
[1]贾锡莲,徐灿坤,周阳,曲竹秋.右归丸对实验性甲状腺功能减退大鼠骨骼肌GluT4 mRNA表达水平的影响[J].中医杂志,2006(09):698-701. DOI： 10.13288/j.11-2166/r.2006.09.036.

Jia Xilian1, Xu Cankun2, Zhou Yang3, et al. Effect of Yougui Wan on GluT4 mRNA Expression in the Skeletal Muscle of Experimental Hypothyroidism Rats[J]. Journal of Traditional Chinese Medicine2006, (9): 698-701. DOI： 10.13288/j.11-2166/r.2006.09.036.

摘要

目的:研究温阳补肾中药右归丸对实验性甲状腺功能减退症大鼠的治疗作用及对骨骼肌葡萄糖转运蛋白4（GluT4）mRNA表达的影响。方法:采用丙基硫氧嘧啶灌胃给药造成实验性甲减大鼠模型

然后给予不同的治疗方案

治疗8周后处死大鼠

取血检测甲状腺功能

取肌肉组织检测GluT4mRNA表达量。结果:模型组大鼠骨骼肌GluT4mRNA表达显著降低

约相当于正常表达水平的14.37%。治疗后右归丸中剂量组、右归丸高剂量组、中西药合用组GluT4mRNA表达明显提高

大致恢复正常范围;而西药组、右归丸低剂量组、自拟方组与模型组相比无明显变化。结论:右归丸能上调甲减大鼠骨骼肌GluT4mRNA表达水平

促进骨骼肌对葡萄糖的转运

从而改善骨骼肌细胞的能量代谢

这可能是中药能有效治疗甲状腺功能减退症的作用机理之一。

Abstract

Objective:To study the effect of Yougui Wan on experimental hypothyroidism and GluT4 mRNA expression in the skeletal muscle of experimental hypothyroidism rats.Methods:Experimental hypothyroidism rat model was made with intragastrical perfusion of propylthiouracil（PUT） and was treated with different treatment programs.After treatment for 8 weeks

the rats were killed and the blood sample was taken for examination of thyroid hormones

and the muscular tissue was taken to detect GluT4 mRNA expression.Results:GluT4 mRNA expression in the skeletal muscle significantly decreased in the model group

corresponding to 14.37% of the normal expression; After treatment

the GluT4 mRNA expression significantly increased to about the normal range in the Yougui Wan mid dose group

Yougui Wan high dose group

and the integrated Chinese and western medicine group.There was no significant changes as the western medicine group

Yougui Wan low dose group

self-stipulated recipe group compared with the model group.Conclusion:Yougui Wan can up-regulate GluT4 mRNA expression in the skeletal muscle of hypothyroidism rats

promoting transport of glucose in the skeletal muscle

so as to improve energy metabolism of the skeletal muscular cells

which is possibly one of the mechanisms of the Chinese medicine effectively treating hypothyroidism.

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