Study on TCM Recipe and Syndrome of Dimethylnitrosamine-induced Hepatic Fibrosis in Rats

Wang Lei; Liu Ping; Mu Yongping; et al.

doi:10.13288/j.11-2166/r.2006.12.031

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Study on TCM Recipe and Syndrome of Dimethylnitrosamine-induced Hepatic Fibrosis in Rats

更新时间：2021-11-17

- Study on TCM Recipe and Syndrome of Dimethylnitrosamine-induced Hepatic Fibrosis in Rats
- Journal of Traditional Chinese Medicine Issue 12, Pages: 929-932(2006)
- 作者机构：
  
  1. 上海中医药大学肝病研究所
  2. 上海中医药大学附属曙光医院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2006.12.031
  CLC： R259
- Published：2006
- 稿件说明：
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[1]王磊,刘平,慕永平,李风华,龙爱华,顾宏图,陈高峰.二甲基亚硝胺大鼠肝纤维化中医方证研究[J].中医杂志,2006(12):929-932.

Wang Lei, Liu Ping, Mu Yongping, et al. Study on TCM Recipe and Syndrome of Dimethylnitrosamine-induced Hepatic Fibrosis in Rats[J]. Journal of Traditional Chinese Medicine2006, (12): 929-932.
[1]王磊,刘平,慕永平,李风华,龙爱华,顾宏图,陈高峰.二甲基亚硝胺大鼠肝纤维化中医方证研究[J].中医杂志,2006(12):929-932. DOI： 10.13288/j.11-2166/r.2006.12.031.

Wang Lei, Liu Ping, Mu Yongping, et al. Study on TCM Recipe and Syndrome of Dimethylnitrosamine-induced Hepatic Fibrosis in Rats[J]. Journal of Traditional Chinese Medicine2006, (12): 929-932. DOI： 10.13288/j.11-2166/r.2006.12.031.

摘要

目的:探讨二甲基亚硝胺（DMN）大鼠肝纤维化的中医方证。方法:腹腔注射法制备DMN大鼠肝纤维化模型

分别采用5首不同功效的经典方治疗两周

观察各组大鼠肝组织病理学、羟脯氨酸（Hyp）含量及肝功能变化。结果:造模4周后大鼠形成典型小结节性肝硬化

6周后模型组大鼠肝组织损伤较4周时有所缓解。与6周模型组相比

茵陈蒿汤组大鼠肝组织病理变化、Hyp含量及肝功能均显著改善（P<0.05或P<0.01）;黄芪汤组大鼠肝组织病理变化、Hyp含量亦显著改善（P<0.05或P<0.01）。结论:茵陈蒿汤、黄芪汤能够有效逆转DMN大鼠肝纤维化

成型期DMN肝纤维化大鼠的主要中医方证为湿热、瘀热内蕴兼气虚。

Abstract

Objective:To probe into TCM recipe and syndrome of dimethylnitrosamine（DMN）-induced hepatic fibrosis of the rat.Methods:DMN rat hapetic fibrosis model was prepared by intraperitoneal injection of DMN

and they were respectively treated with 5 classical recipes with difference functions for 2 weeks.Changes of pathology of the hepatic tissue

hydroxyproline（Hyp） content and hapetic function were investigated.Results:4 weeks after modeling

typical micronodular cirrhosis formed

and 6 weeks after modeling

the hepatic injury in the model group had some remission as compared with that at 4 weeks.Compared with the model group at 6 weeks

pathologic changes of the hepatic tissue

Hyp content and hepatic function improved significantly（P<0.05 or P<0.01） in the Inchenhao Decoction group;pathologic changes of the hepatic tissue and Hyp content in the Huangqi Decoction group improved significantly（P<0.05 or P<0.01）.Conclusion:Inchenhao Decoction and Huangqi Decoction can effectively reverse DMN-induced hepatic fibrosis of rats;damp-heat

stagnation of heat in the interior with qi-deficiency are main TCM syndromes of DMN hepatic fibrosis rat at the formative stage.

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