Objective:To observe regulative effects of Yangyin Yiqi Liangxue Mixture and its different groups of Chinese herbs on immunologic function in immunosuppression mice induced by exogenous glucocorticoid hormone.Methods:The mixture was divided into a nourishing-yin group [Xuanshen（Radix Scrophulariae）

Huafen（Radix Trichosanthis）

Huangjing（Rhizoma Polygonati）]

a supplementing-qi group [Huangqi（Radix Astragali）

Renshen（Radix Ginseng）] and a cooling-blood group[Zicao（Radix Arnebiae seu Lithospermi）].After immunosuppression of CRI mice was induced by intramuscular injection of exogenous glucocorticoid hormone

administed decoctions for nourishing yin

supplementing qi

cooling blood and the whole recipe

respectively.The concentration of decoction for each group was 5g crude drug/kg body weight.Proliferation of lymphocytes

the phagocytosis of macrophage in abdominal cavity and cytotoxicity of NK cells were determined.Results:Compared with the model group

the nourishing yin group

the supplementing qi group

the cooling blood group and the whole recipe could increase significantly proliferative activities of lymphocytes in immunosuppression mice（P<0.01）.Activity of NK cells and phagocytosis of macrophages in administration groups expect cooling-blood group were improved significantly（P<0.01）.The improvement of spleen index in each group was not significant.Conclusion:Yangyin Yiqi Liangxue Mixture and the drugs for nourishing yin

supplementing qi in the recipe can increase specific and non-specific immunologic functions in the mouse of immunosuppression in varying degrees

with the drugs for supplementing qi closing the whole recipe in some functions

and the drugs for nourishing yin being the next.