Objective To study the clinical effect of Diabetic Foot Formula （DFF） and its influence on hemodynamics of arteria dorsalis pedis （ADP）.Methods Totally 108 cases of DF were randomly divided into DFF group and western medicine group

each containing 54 cases.DFF group was treated by DFF

while western medicine group by anisodamine.Clinical effect and hemodynamic change of ADP in both groups were observed before and after treatment.Thirty five healthy persons were selected as healthy control group.Results In comparison with western medicine group

granulation tissue formation time （GT） and ulceration healing time （HT） were shorter

healing rate was higher

amputation rate was lower in DFF group

resulting in significant differences （P<0.05 or P<0.01）.In comparison with healthy control group

DF patients had smaller inner diameter of ADP

quicker peak flow rate

lower blood flow

and wider spectral width.After treatment

hemodynamic index of ADP improved in both treatment groups （P<0.01）

espically in DFF group （P<0.05）.Conclusion The effect of complex treatment mainly consisting of DDF is superior to that of anisodamine.