Objective To explore the pathogenesis of drug-induced liver injury and the therapeutic mechanism of Baogan Jiedu Granules.Methods Totally 60 mice were randomly divided into 6 groups.They were treated with intragastrical perfusion of corresponding doses of drugs for 5 days

respectively and then were modeled by intragastrical perfusion of Tripterygium Wilfordii Polyglycoside.Serum ALT

AST and IL-18 levels and apoptosis of hepatic cells were detected.Results IL-18 level in model group increased obviously with severe apoptosis of hepatic cells.Baogan Jiedu Granules could effectively decrease ALT

AST activities and IL-18 level with apoptosis of hepatic cells obviously improved.Conclusion Leigongteng Duodai-induced acute liver injury is closely correlated with IL-18 and apoptosis of hepatic cells.Baogan Jiedu Granules has therapeutic effect for liver injury through decreasing IL-18 level and inhibiting apioptosis of hepatic cells.