Objective To study the effect of Tongfu Qingxia Decoction on the barrier function and inflammatory reaction regulation of intestinal mucosa in acute pancreatitis patients.Methods Patients selected were randomly divided into two groups.Routine treatment was conducted in control group

while Tongfu Qingxia Decoction was added in treatment group.Plasmic endotoxin

tumor necrosis factor-α（TNF-α）and interleukin-6（IL-6）were observed before and after treatment.Results After treatment

plasmic endotoxin

TNF-α and IL-6 decreased and interleukin-2 increased significantly in both groups（P<0.05）

especially in treatment group（P<0.05）.Conclusion In comparison with simple western treatment

the combination of Tongfu Qingxia Decoction can regulate immune function

relieve acute inflammatory reaction

decrease the level of TNF-α and endotoxin

improve internal environment and promote the relief and rehabilitation from AP obviously.