Effect of Yin-Enriching Fire-Draining and Heat-Clearing Damp-Drying Chinese Herbs on Obesity and Sexual Development Index in Female Rats

CUI Hong; YANG Ai-jun; YE Hui-chu; et al.

doi:10.13288/j.11-2166/r.2007.04.035

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Effect of Yin-Enriching Fire-Draining and Heat-Clearing Damp-Drying Chinese Herbs on Obesity and Sexual Development Index in Female Rats

更新时间：2021-11-17

- Effect of Yin-Enriching Fire-Draining and Heat-Clearing Damp-Drying Chinese Herbs on Obesity and Sexual Development Index in Female Rats
- Journal of Traditional Chinese Medicine Issue 4, Pages: 351-353(2007)
- 作者机构：
  
  1. 首都医科大学附属北京友谊医院
  2. 首都医科大学北京市宣武区永安路95号
  3. ,100050
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2007.04.035
  CLC： R285.5
- Published：2007
- 稿件说明：
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[1]崔红,杨爱君,叶卉初,崔雁,李贵,李宇航.滋阴泻火、清热燥湿中药对雌性大鼠肥胖和性发育相关指标的影响[J].中医杂志,2007(04):351-353.

CUI Hong, YANG Ai-jun, YE Hui-chu, et al. Effect of Yin-Enriching Fire-Draining and Heat-Clearing Damp-Drying Chinese Herbs on Obesity and Sexual Development Index in Female Rats[J]. Journal of Traditional Chinese Medicine2007, (4): 351-353.
[1]崔红,杨爱君,叶卉初,崔雁,李贵,李宇航.滋阴泻火、清热燥湿中药对雌性大鼠肥胖和性发育相关指标的影响[J].中医杂志,2007(04):351-353. DOI： 10.13288/j.11-2166/r.2007.04.035.

CUI Hong, YANG Ai-jun, YE Hui-chu, et al. Effect of Yin-Enriching Fire-Draining and Heat-Clearing Damp-Drying Chinese Herbs on Obesity and Sexual Development Index in Female Rats[J]. Journal of Traditional Chinese Medicine2007, (4): 351-353. DOI： 10.13288/j.11-2166/r.2007.04.035.

摘要

目的观察滋阴泻火、清热燥湿中药对营养性肥胖大鼠的减重效果及性发育相关指标的影响。方法建立营养性肥胖动物模型

灌喂中药

观察其体重、耐疲劳能力、血清性激素水平及卵巢发育情况。结果灌喂中药后

可以使大鼠体重明显减轻

但不影响其身长和负重游泳时间

并可以使其血脂、肝脏脂肪变发生率降低;中药还可以使血中雌二醇水平、同期黄体出现率降低

下丘脑促性腺激素释放激素表达下降。结论滋阴泻火、清热燥湿中药对雌性大鼠有明显的减重作用

使肝脂肪变的发生率降低

未见副作用

可能与该类中药调整其性腺轴、抑制肥胖时性成熟提前倾向有关。

Abstract

Objective To study the effect of yin-enriching fire-draining and heat-clearing damp-drying Chinese herbs on weight reduction and sexual development index（SDI）in rats with alimentary obesity.Methods Chinese herbs were fed to alimentary obesity model rats and their body weight

fatigued endurance

serum sexual hormone and ovarian development condition were tested.Results After model rats were drenched

body weight

blood lipid

incidence of fatty liver

level of E2

frequency of corepus luteum

expression of hypothalamic GnRH decreased obviously.But there was no change in body length and time of weighted swimming.Conclusion Yin-enriching fire-draining and heat-clearing damp-drying Chinese herbs can reduce female rats’ body weight and incidence of fatty liver obviously without adverse effect.Its effect may be relevant to regulating gonadal axis and inhibiting sexual precosity.

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