Experimental Therapeutic Effect of Tumor Cell Vaccine Constructed by Curcumol on Gastric Cancer

XU Li-chun1; BU Ping1; XU Xiang-yu2; et al.

doi:10.13288/j.11-2166/r.2007.05.040

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Experimental Therapeutic Effect of Tumor Cell Vaccine Constructed by Curcumol on Gastric Cancer

更新时间：2021-11-17

- Experimental Therapeutic Effect of Tumor Cell Vaccine Constructed by Curcumol on Gastric Cancer
- Journal of Traditional Chinese Medicine Issue 5, Pages: 450-452(2007)
- 作者机构：
  
  1. 扬州大学中西医结合研究所
  2. 南京军区军事医学研究所
  3. 江苏省苏北人民医院
  4. 扬州大学中西医结合研究所江苏省扬州市淮海路11号
  5. ,225001
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2007.05.040
  CLC： R285.5
- Published：2007
- 稿件说明：
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[1]徐立春,卜平,许祥裕,陈平,边可君,周娟,刘志敏,孙振华.中药莪术醇构建胃癌细胞疫苗对胃癌的实验治疗效果[J].中医杂志,2007(05):450-452.

XU Li-chun1, BU Ping1, XU Xiang-yu2, et al. Experimental Therapeutic Effect of Tumor Cell Vaccine Constructed by Curcumol on Gastric Cancer[J]. Journal of Traditional Chinese Medicine2007, (5): 450-452.
[1]徐立春,卜平,许祥裕,陈平,边可君,周娟,刘志敏,孙振华.中药莪术醇构建胃癌细胞疫苗对胃癌的实验治疗效果[J].中医杂志,2007(05):450-452. DOI： 10.13288/j.11-2166/r.2007.05.040.

XU Li-chun1, BU Ping1, XU Xiang-yu2, et al. Experimental Therapeutic Effect of Tumor Cell Vaccine Constructed by Curcumol on Gastric Cancer[J]. Journal of Traditional Chinese Medicine2007, (5): 450-452. DOI： 10.13288/j.11-2166/r.2007.05.040.

摘要

目的研究莪术醇修饰构建的肿瘤细胞疫苗对人胃腺癌细胞（SGC-7901）等的抗瘤作用。方法用莪术醇及新城鸡瘟病毒对SGC-7901细胞进行系列生物修饰

所构建的瘤苗分别对小鼠免疫接种3次后

接种SGC-7901胃肿瘤细胞

观察各组治疗及免疫效应。结果莪术醇构建的SGC-7901瘤苗能显著抑制皮下肿瘤结节形成

明显阻止胃癌细胞的肺转移

延长荷瘤鼠的生存时间。各组免疫效应淋巴因子激活的杀伤细胞（LAK细胞）较同龄未免疫小鼠的LAK细胞对小鼠前胃癌细胞具有更强的抗瘤作用。结论莪术醇修饰构建的SGC-7901新型疫苗可以增强胃肿瘤细胞的免疫原性

对胃癌有较好的实验治疗效果。

Abstract

Objective To study the therapeutic effect of tumor cell vaccine modified and constructed by curcumol on SGC-7901 cells. Methods SGC-7901 cells were modified by curcumol and Newcastle disease virus. The mice were vaccinated with tumor vaccine three times

then SGC-7901 cells. The therapeutic and immunological effect was observed. Results SGC-7901 cells constructed by curcumol could inhibit the formation of subcutaneous tumor nodule

interrupt pulmonary metastasis and extend the live time of mice bearing cancer. Immunizing lympholine-activated killer cells had better anticancer function than nonimmune ones. Conclusion SGC-7901 cells modified and constructed by curcumol can enhance immunogenicity of gastric tumor cells and experimentally cure gastric cancer.

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