CAI Jing1, DU Jian1, LIU Xi-fei2, et al. Effect of Kangxin Capsule and Its Different Compositions on Nerve Cells of Rats with Kidney Deficiency and Blood Stasis[J]. Journal of Traditional Chinese Medicine2007, (5): 453-456.
CAI Jing1, DU Jian1, LIU Xi-fei2, et al. Effect of Kangxin Capsule and Its Different Compositions on Nerve Cells of Rats with Kidney Deficiency and Blood Stasis[J]. Journal of Traditional Chinese Medicine2007, (5): 453-456.DOI: 10.13288/j.11-2166/r.2007.05.041.
Effect of Kangxin Capsule and Its Different Compositions on Nerve Cells of Rats with Kidney Deficiency and Blood Stasis
Objective To study Kangxin Capsule and its kidney-supplementing
spleen-fortifying and blood-nourishing-quickening compositions on nerve cells of vascular dementia (VD) rats with kidney deficiency and blood stasis. Methods Hibateral vertebral arteries were permanently blocked and unilateral genital was extirpated to establish VD rat models with kidney deficiency and blood stasis. Hydergine
distilled water
Kangxin Capsule and its kidney-supplementing
spleen-fortifying and blood-nourishing-quickening compositions were given to rat models respectively. Results Kangxin Capsule could improve spatial exploration ability of rats
relieve pycnosis of nerve cells in hippocampus
increase the content of acetylcholine
up-regulate the expression of tyrosine kinase A
nuclear transcription factor-κB
C-fos and Nerve growth factor receptor and down-regulate the expression of glial fibrillary acidic protein significantly as compared with other groups (P<0.01 or P<0.05). Conclusion Kangxin Capsule has a protective effect on nerve cells of VD rats with kidney deficiency and blood stasis.
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Related Author
Li Haixia
CUI Weilu
QIU Hongfan
CHEN Yanxia1
DAI Dong2
YU Tao2
XU Wengui 2
SHI Jiangwei 3
Related Institution
Guang 'anmen Hospital,China Academy of Chinese Medical Sciences
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
Tianjin Municipal Tumour Hospital
Tianjin University of Traditional Chinese Medicine