Effect of Shenqi Compound Recipe on the Expression of PPARγ in White Adipose Tissue of Rats with Macrovascular Complication in Earlier Stage of Diabetes

ZHANG Hong-min1; XIE Chun-guang2; CHEN Shi-wei3; et al.

doi:10.13288/j.11-2166/r.2007.06.038

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Effect of Shenqi Compound Recipe on the Expression of PPARγ in White Adipose Tissue of Rats with Macrovascular Complication in Earlier Stage of Diabetes

更新时间：2021-11-17

- Effect of Shenqi Compound Recipe on the Expression of PPARγ in White Adipose Tissue of Rats with Macrovascular Complication in Earlier Stage of Diabetes
- Journal of Traditional Chinese Medicine Issue 6, Pages: 549-551(2007)
- 作者机构：
  
  1. 四川大学华西医院中西医结合科及中药药理研究室
  2. 成都中医药大学中医内科教研室
  3. 河南省食品药品监督管理局
  4. 成都中医药大学成都市外南国学巷37号
  5. ,610041
  6. 级博士研究生,2003
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2007.06.038
  CLC： R285.5
- Published：2007
- 稿件说明：
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[1]张红敏,谢春光,陈世伟,谢毅强.参芪复方对糖尿病早期大血管病变大鼠白色脂肪过氧化物酶体增生物激活受体γ的影响[J].中医杂志,2007(06):549-551+562.

ZHANG Hong-min1, XIE Chun-guang2, CHEN Shi-wei3, et al. Effect of Shenqi Compound Recipe on the Expression of PPARγ in White Adipose Tissue of Rats with Macrovascular Complication in Earlier Stage of Diabetes[J]. Journal of Traditional Chinese Medicine2007, (6): 549-551.
[1]张红敏,谢春光,陈世伟,谢毅强.参芪复方对糖尿病早期大血管病变大鼠白色脂肪过氧化物酶体增生物激活受体γ的影响[J].中医杂志,2007(06):549-551+562. DOI： 10.13288/j.11-2166/r.2007.06.038.

ZHANG Hong-min1, XIE Chun-guang2, CHEN Shi-wei3, et al. Effect of Shenqi Compound Recipe on the Expression of PPARγ in White Adipose Tissue of Rats with Macrovascular Complication in Earlier Stage of Diabetes[J]. Journal of Traditional Chinese Medicine2007, (6): 549-551. DOI： 10.13288/j.11-2166/r.2007.06.038.

摘要

目的观察参芪复方对糖尿病早期大血管病变大鼠白色脂肪过氧化物酶体增生物激活受体γ（PPARγ）的影响。方法模型组、雷米普利组、参芪复方低剂量组、高剂量组及正常对照组分别给予相应受试物32天。实时定量RT-PCR法检测脂肪PPARγ和脂联素mRNA的表达。结果参芪复方低剂量组、高剂量组大鼠的PPARγ及其下游靶基因脂联素mRNA表达量均较模型组明显增加

且二者呈明显正相关关系。结论上调和活化PPARγ可能是参芪复方抗糖尿病早期大血管病变的作用机制之一。

Abstract

Objective To study the effect of Shenqi Compound Recipe （SCR） on the expression of peroxisome proliferator-activated receptor γ （PPARγ） in white adipose tissue of rats with macrovascular complication in earlier stage of diabetes. Methods Corresponding substance was given to rats in model group

Ramipril group

normal control group and low or high dosage of SCR groups respectively for 32 days. The expression of PPARγ and adiponectin mRNA was tested by real-time reverse transcriptase polymerase chain reaction. Results The expression of PPARγ and adiponectin mRNA increased obviously in low and high dosage of SCR groups as compared with model group. There was positive correlation between expression of PPARγ and adiponectin mRNA. Conclusion SCR can prevent macrovascular complication in earlier stage of diabetes

which might be relevant to its up-regulating and activating PPARγ.

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