Objective To study the effect of Runing Ⅱ（Herbal Formula for Mammary Cancer） on the growth and metastasis of transplanted tumor of mammary cancer MA-891 TA2 mice and its mechanism.-Methods The models of mammary cancer MA-891 cell strain of transplanted tumor of TA2 mice with lung metastasis were made to observe the effect of Runing Ⅱ on the growth and metastasis of transplanted tumor.The immunohistochemical method and image analysis were adopted to test the level of vascular endothelial growth factor（VEGF）

vascular endothelial growth factor receptor（VEGFR）

and microvessel count（MVC）

and microvessel area（MVA）.-Results In the Runing Ⅱ group

the tumor weight inhibition rate and the lung metastasis inhibition rate were 37.3% and 65.4% respectively

the growth and metastasis were obviously inhibited;the level of VEGF

VEGFR

MVC and MVA was significantly lowered as compared with those of the tumor-control group（P<0.05）.-Conclusion The herbal formula Runing Ⅱ can inhibit the metastasis of tumor through inhibiting the angiogenesis

its mechanism may be related to lowering the level of VEGF and the expression of VEGFR.