Effect of Nourishing Yin and Promoting Blood Circulation Formula on Ventricular Remodeling of Transgenic Mice with Mineralocorticoid Receptor Overexpression

HUA Hao-ming1; YAMAMOTO Yasuhiro2; QIU Zhi-gang2; et al.

doi:10.13288/j.11-2166/r.2007.10.049

您当前的位置：

首页 >

文章列表页 >

Effect of Nourishing Yin and Promoting Blood Circulation Formula on Ventricular Remodeling of Transgenic Mice with Mineralocorticoid Receptor Overexpression

更新时间：2021-11-17

- Effect of Nourishing Yin and Promoting Blood Circulation Formula on Ventricular Remodeling of Transgenic Mice with Mineralocorticoid Receptor Overexpression
- Journal of Traditional Chinese Medicine Issue 10, Pages: 927-930(2007)
- 作者机构：
  
  1. 南京中医药大学基础医学院
  2. 大阪大学大学院药学研究科
  3. 南京中医药大学基础医学院南京市汉中路282号
  4. ,210029
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2007.10.049
  CLC： R285.5
- Published：2007
- 稿件说明：
移动端阅览
[1]华浩明,山本泰弘,邱志刚,东纯一,王灿晖,杨进.养阴活血方对转基因盐皮质激素受体过度表达小鼠模型心室重塑的影响[J].中医杂志,2007(10):927-930.

HUA Hao-ming1, YAMAMOTO Yasuhiro2, QIU Zhi-gang2, et al. Effect of Nourishing Yin and Promoting Blood Circulation Formula on Ventricular Remodeling of Transgenic Mice with Mineralocorticoid Receptor Overexpression[J]. Journal of Traditional Chinese Medicine2007, (10): 927-930.
[1]华浩明,山本泰弘,邱志刚,东纯一,王灿晖,杨进.养阴活血方对转基因盐皮质激素受体过度表达小鼠模型心室重塑的影响[J].中医杂志,2007(10):927-930. DOI： 10.13288/j.11-2166/r.2007.10.049.

HUA Hao-ming1, YAMAMOTO Yasuhiro2, QIU Zhi-gang2, et al. Effect of Nourishing Yin and Promoting Blood Circulation Formula on Ventricular Remodeling of Transgenic Mice with Mineralocorticoid Receptor Overexpression[J]. Journal of Traditional Chinese Medicine2007, (10): 927-930. DOI： 10.13288/j.11-2166/r.2007.10.049.

摘要

目的观察养阴活血方对转基因（TG）盐皮质激素受体（MR）过度表达小鼠模型心室重塑的影响。方法将小鼠分为3组

即雄性非转基因小鼠组（NTG组）、雄性转基因小鼠组（TG组）和雄性转基因小鼠加中药组（TG+K组）

心肌梗死造模后观察心脏重量和心脏重量/体重比、脑钠肽（BNP）的mRNA表达、生存率和心脏病理切片。结果养阴活血方干预治疗后

TG+K组心脏重量和心脏重量/体重比与TG组比较差异均有显著性意义（P<0.05）

但与NTG组比较

差异无显著性意义（P>0.05）;TG+K组的BNPmRNA较TG组表达减弱（P<0.05）

较NTG组差异无显著性意义（P>0.05）;TG+K组生存率高于TG组（P<0.05）

与NTG组比较差异无显著性意义（P>0.05）;心脏病理切片显示

TG组心脏纤维化明显

TG+K组心脏纤维化减轻

而NTG组最轻。结论养阴活血方可减轻雄性TGMR心肌梗死小鼠模型的心室重塑。

Abstract

Objective To observe the influence of Nourishing Yin and Promoting Blood Circulation Formula on ventricular remodeling of transgenic mice with mineralocorticoid receptor overexpression.Methods The mice were divided into three groups:male non-transgene（NTG）group

male transgene（TG）group

and male transgene + Chinese medicine（TG+herbs）group.After myocardial infarction model-making

the heart weight

ratio of heart weight to body weight

mRNA expression of brain natriuretic peptide

survival rate and heart pathological section were observed.Results With the herbal treatment to nourish yin and promote blood circulation

the heart weight and the ratio of heart weight to body weight of the TG+herbs group was significantly different from those of TG group（P<0.05）

but the difference was not significant in comparison with NTG group（P>0.05）.The mRNA expression of brain natriuretic peptide of TG+herbs group was weakened than that of TG group（P<0.05）

but the difference was not significant in comparison with NTG group（P>0.05）.The survival rate of TG+herbs group was higher than that of TG group（P<0.05）

but the difference was not significant in comparison with NTG group（P>0.05）.The heart pathological section showed an obvious fibrosis in TG group

a relieved fibrosis in TG+herbs group and a least fibrosis in NTG group.Conclusion The herbal treatment to nourish yin and promote blood circulation can relieve the ventricular remodeling of male TG mice with MR overexpression after myocardial infarction.

关键词

Keywords

references

查看原文

Views

139

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Effect of Shengmai Powder on Ventricular Remodeling and Quality of Life of Chronic Heart Failure Patients

Construction and Application of a Real-World Cohort of Community-Acquired Pneumonia Based on a Multimodal Large-Scale Traditional Chinese Medicine Big Data Platform

Effect of Xiaoqinglong Decoction （小青龙汤） on Th2 Immune Responses and Nasal Mucosal TSLP/OX40L Pathway in Allergic Rhinitis Model Rats

Exploring the Comorbidity Mechanism，Prevention and Treatment Strategies of Rheumatoid Arthritis with Coronary Atherosclerotic Heart Disease Based on Collateral Disease Theory

Current Status and Strategic Recommendations for Randomized Controlled Trials on Functional Dyspepsia-Irritable Bowel Syndrome Comorbidity：from a Real-World Research Perspective

Related Author

GU Yingmin

YE Suilin

SUN Ying

et al.

吴文锋

黄洁红

何皓颋

高雅琦

Related Institution

Guangzhou Hospital of TCM

Address：No.16, Nanxiao street, Dongzhimen, Dongcheng District, Beijing Postal code：100700
Tel：010-64035632 Email：jtcmcn@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备09064830号-19 京公网安备11010102007558号
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰