Changes of Blood Lipid,Blood Rheology and Microcirculation of Model Rats of Diabetes Ⅱ with Heart Blood Stasis Syndrome

XIE Meng-zhou TIAN Hao-mei CHEN Chu-tao

doi:10.13288/j.11-2166/r.2007.12.033

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Changes of Blood Lipid,Blood Rheology and Microcirculation of Model Rats of Diabetes Ⅱ with Heart Blood Stasis Syndrome

更新时间：2021-11-17

- Changes of Blood Lipid,Blood Rheology and Microcirculation of Model Rats of Diabetes Ⅱ with Heart Blood Stasis Syndrome
- Journal of Traditional Chinese Medicine Issue 12, Pages: 1119-1121(2007)
- 作者机构：
  
  1. 湖南中医药大学中医诊断研究所
  2. 湖南中医药大学中医诊断研究所长沙市韶山中路113号
  3. ,410007
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2007.12.033
  CLC： R259
- Published：2007
- 稿件说明：
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[1]谢梦洲,田浩梅,陈楚淘,莫楠,李露丹,何军锋,喻道贵.2型糖尿病心血瘀证模型大鼠血脂、血液流变学、微循环的变化[J].中医杂志,2007(12):1119-1121.

XIE Meng-zhou TIAN Hao-mei CHEN Chu-tao. Changes of Blood Lipid,Blood Rheology and Microcirculation of Model Rats of Diabetes Ⅱ with Heart Blood Stasis Syndrome[J]. Journal of Traditional Chinese Medicine2007, (12): 1119-1121.
[1]谢梦洲,田浩梅,陈楚淘,莫楠,李露丹,何军锋,喻道贵.2型糖尿病心血瘀证模型大鼠血脂、血液流变学、微循环的变化[J].中医杂志,2007(12):1119-1121. DOI： 10.13288/j.11-2166/r.2007.12.033.

XIE Meng-zhou TIAN Hao-mei CHEN Chu-tao. Changes of Blood Lipid,Blood Rheology and Microcirculation of Model Rats of Diabetes Ⅱ with Heart Blood Stasis Syndrome[J]. Journal of Traditional Chinese Medicine2007, (12): 1119-1121. DOI： 10.13288/j.11-2166/r.2007.12.033.

摘要

目的探讨2型糖尿病心血瘀证模型大鼠的血脂、血液流变学、球结膜微循环之间的关系。方法采用高脂高热量饲料喂养并结合小剂量链脲佐菌素（STZ）腹腔注射的方法制备2型糖尿病大鼠模型的基础上

再行地塞米松和肾上腺素腹腔注射制备2型糖尿病心血瘀证大鼠模型。空腹8小时后麻醉大鼠

测球结膜微循环、颈动脉取血测血脂、血液流变学。结果该模型鼠血脂、血液流变学和球结膜微循环指标均出现异常

符合糖尿病心血管并发症的变化规律。

Abstract

Objective To explore the relations among blood lipid

blood rheology and microcirculation of bulbar conjunctiva of model rats of diabetesⅡwith heart blood stasis syndrome.Methods The rats were fed with high fat and caloric feed.Intraperitoneal injection of streptozotocin（STZ）in small dosage was applied to make the model of diabetesⅡ.Then the model of heart blood stasis syndrome was made through introperitoneal injecting dexamethasone and adrenalin.Eight hours after empty stomach

the rats were anaesthetized to measure the microcireulation of bulbar conjunctiva and test the blood lipid and carotid blood rheology.Results The indices of blood lipid

blood rheology and bulbar eonjunetiva microcirculation of model rats were all changed to abnormal

tallying with the changes of cardiovascular complications of diabetes.

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