Objective To compare the effect for decreasing blood glucose（BG） and reducing body weight on obese diabetics of typeⅡwith Feitangluo"Holistic Treatment"and traditional TCM therapy for Xiaoke（diabetes）

and to evaluate clinical application range

untoward reaction and safety.Methods The 216 obese diabetics of typeⅡwere randomized into two groups

the treatment group treated by Holistic Treatment and the control group by Liuwei Dihuang Capsule（Capsule of Six Ingredients with Rehmannia）.The treatment lasted 12 weeks

and body weight index（BWI）

waist/hip ratio（WHR）

fasting blood glucose（FBG） and BG 2h after meal were observed.Results In the treatment group

the effective rate in decreasing BG was 74.1% and in losing weight 81.5%.In the control group

the effective rate in decreasing BG was 42.6% and in losing weight 30.1%.The difference was significant（P<0.05）. There was no untoward reaction seen in both groups.Conclusion Holistic Treatment is safe and effective.Its prescription modifica- tion accords with the law based on TCM syndrome differentiation on diabetes

applicable for diabetes typeⅡwith obesity.