Effect and Mechanism of Yinchen Wuling Powder on Atherosclerosis Rats

WANG Dong-Sheng TANG Fa-Qing XIAO Chang-Jiang et al.

doi:10.13288/j.11-2166/r.2008.01.047

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Effect and Mechanism of Yinchen Wuling Powder on Atherosclerosis Rats

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- Effect and Mechanism of Yinchen Wuling Powder on Atherosclerosis Rats
- Journal of Traditional Chinese Medicine Issue 1, Pages: 67-69(2008)
- 作者机构：
  
  1. 中南大学湘雅医院
  2. 湖南中医学院
  3. 中南大学湘雅医院湖南省长沙市湘雅路87号
  4. ,410008
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2008.01.047
  CLC： R285.5
- Published：2008
- 稿件说明：
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[1]王东生,唐发清,肖长江,陈方平,袁肇凯,黄献平,郭志华.茵陈五苓散抗大鼠动脉粥样硬化作用机理探讨[J].中医杂志,2008(01):67-69.

WANG Dong-Sheng TANG Fa-Qing XIAO Chang-Jiang et al.. Effect and Mechanism of Yinchen Wuling Powder on Atherosclerosis Rats[J]. Journal of Traditional Chinese Medicine2008, (1): 67-69.
[1]王东生,唐发清,肖长江,陈方平,袁肇凯,黄献平,郭志华.茵陈五苓散抗大鼠动脉粥样硬化作用机理探讨[J].中医杂志,2008(01):67-69. DOI： 10.13288/j.11-2166/r.2008.01.047.

WANG Dong-Sheng TANG Fa-Qing XIAO Chang-Jiang et al.. Effect and Mechanism of Yinchen Wuling Powder on Atherosclerosis Rats[J]. Journal of Traditional Chinese Medicine2008, (1): 67-69. DOI： 10.13288/j.11-2166/r.2008.01.047.

摘要

目的探讨茵陈五苓散对动脉粥样硬化大鼠的作用机理。方法70只雄性Wistar大鼠随机分为正常组、模型组、茵陈五苓散组、绞股蓝组。采用高脂饲料喂饲法复制大鼠动脉粥样硬化模型

治疗1个月后分别检测血脂、血液流变学、主动脉组织学及超微结构变化、血管平滑肌细胞（VSMC）bcl-2 mRNA的表达。结果茵陈五苓散降低总胆固醇、甘油三酯、低密度脂蛋白胆固醇

升高高密度脂蛋白胆固醇

降低血液黏度、红细胞压积、血小板黏附率

维持主动脉组织结构

下调基因bcl-2 mRNA的表达均优于绞股蓝。结论茵陈五苓散具有良好的抗动脉粥样硬化作用

其下调相关基因bcl-2 mRNA的表达可能是其作用机理。

Abstract

Objective To study the effect and mechanism of Yinchen Wuling Powder（Powder of Oriental Wormwood and Five Herbs with Poria） on atherosclerosis（AS） rats.Methods Totally 70 Wistar rats were randomized into normal group

model group

Yinchen Wuling Powder group

and Gypenosides group.The AS models were made by feeding greasy food for producing AS plague in aorta.The serum lipid

blood rheology

uhrastructure of aorta tissues

and bcl-2 mRNA expression of VSMC were tested after one month to see the changes.Results Yinchen Wuling Powder could obviously decrease the total cholesterol

triglyceride

and low den- sity lipoprotein cholesterol;increase the high density lipoprotein cholesterol;reduce the blood viscosity

packed cell volume

and platelet adhesion rate;maintain the aorta structure;and lower the bcl-2mRNA expression.The effect was better than that of Gypeno- sides.Conclusion Yinchen Wuling Powder has a significant effect on AS and its functional mechanism may lie in lowering the bcl-2 mRNA expression.

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