Analysis on the Monoamine Neurotransmitters in Hypothalamus of Rat Models of Liver-qi Stagnation Syndrome

ZHANG Hui-yun; QIAO Ming-qi; SUN Li

doi:10.13288/j.11-2166/r.2008.02.016

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Analysis on the Monoamine Neurotransmitters in Hypothalamus of Rat Models of Liver-qi Stagnation Syndrome

更新时间：2021-11-17

- Analysis on the Monoamine Neurotransmitters in Hypothalamus of Rat Models of Liver-qi Stagnation Syndrome
- Journal of Traditional Chinese Medicine Issue 2, Pages: 150-152(2008)
- 作者机构：
  
  1. 山东中医药大学科技处
  2. 山东中医药大学科技处济南市长清大学科技园大学路4655号
  3. ,250355
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2008.02.016
  CLC： R256.4
- Published：2008
- 稿件说明：
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[1]张惠云,乔明琦,孙丽.肝气郁证模型大鼠下丘脑单胺类神经递质分析[J].中医杂志,2008(02):150-152.

ZHANG Hui-yun, QIAO Ming-qi, SUN Li. Analysis on the Monoamine Neurotransmitters in Hypothalamus of Rat Models of Liver-qi Stagnation Syndrome[J]. Journal of Traditional Chinese Medicine2008, (2): 150-152.
[1]张惠云,乔明琦,孙丽.肝气郁证模型大鼠下丘脑单胺类神经递质分析[J].中医杂志,2008(02):150-152. DOI： 10.13288/j.11-2166/r.2008.02.016.

ZHANG Hui-yun, QIAO Ming-qi, SUN Li. Analysis on the Monoamine Neurotransmitters in Hypothalamus of Rat Models of Liver-qi Stagnation Syndrome[J]. Journal of Traditional Chinese Medicine2008, (2): 150-152. DOI： 10.13288/j.11-2166/r.2008.02.016.

摘要

目的探讨肝气郁证模型大鼠发病的微观机制。方法捆绑法造模制作肝气郁证模型大鼠

采用反相离子高效液相色谱（RP-IP-HPLC）测定大鼠造模后下丘脑中去甲肾上腺素（NE）、肾上腺素（E）、多巴胺（DA）及5-羟色胺（5-HT）4种神经递质含量变化。结果肝气郁证模型大鼠下丘脑中E、DA、5-HT水平显著升高（P<0.05或P<0.01）

NE水平显著降低（P<0.01）

且用药后均得到明显改善。结论肝气郁证与下丘脑中NE、E、DA、5-HT关系密切。

Abstract

Objective To study the mechanism of liver-qi stagnation syndrome of rat models. Methods The binding method was used to make rat models of liver-qi stagnation syndrome and the quantitative changes of hypothalamus norepinephrine （NE）

epinephrine （E）

dopamine （DA）

and 5-hydroxytryptamine （5-HT） before and after modeling were determined with reversed phase ion pair （RP-IP）-HPLC. Results The level of E

DA and 5-HT was remarkably increased （P<0.05 or P<0.01） while NE decreased significantly （P<0.01）

and they were all improved after medication. Conclusion The liver-qi stagnation syndrome is closely related with level of hypothalamus NE

DA and 5-HT.

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