Effect of Separated Formula for Resolving Phlegm and Promoting Blood Circulation on PPARα mRNA of the Liver of Hyperlipemia Model Rats

WEN Li1; YE Yong2; LIU Song-lin1; et al.

doi:10.13288/j.11-2166/r.2008.03.041

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Effect of Separated Formula for Resolving Phlegm and Promoting Blood Circulation on PPARα mRNA of the Liver of Hyperlipemia Model Rats

更新时间：2021-11-17

- Effect of Separated Formula for Resolving Phlegm and Promoting Blood Circulation on PPARα mRNA of the Liver of Hyperlipemia Model Rats
- Journal of Traditional Chinese Medicine Issue 3, Pages: 261-263(2008)
- 作者机构：
  
  1. 湖北中医学院中医系
  2. 江汉大学医学与生命科学学院
  3. 湖北中医学院中医系武汉市武昌区昙华林特1号
  4. ,430061
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2008.03.041
  CLC： R285
- Published：2008
- 稿件说明：
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[1]闻莉,叶勇,刘松林,梅国强.化痰活血方拆方对高脂血症大鼠肝脏PPARα mRNA的影响[J].中医杂志,2008(03):261-263.

WEN Li1, YE Yong2, LIU Song-lin1, et al. Effect of Separated Formula for Resolving Phlegm and Promoting Blood Circulation on PPARα mRNA of the Liver of Hyperlipemia Model Rats[J]. Journal of Traditional Chinese Medicine2008, (3): 261-263.
[1]闻莉,叶勇,刘松林,梅国强.化痰活血方拆方对高脂血症大鼠肝脏PPARα mRNA的影响[J].中医杂志,2008(03):261-263. DOI： 10.13288/j.11-2166/r.2008.03.041.

WEN Li1, YE Yong2, LIU Song-lin1, et al. Effect of Separated Formula for Resolving Phlegm and Promoting Blood Circulation on PPARα mRNA of the Liver of Hyperlipemia Model Rats[J]. Journal of Traditional Chinese Medicine2008, (3): 261-263. DOI： 10.13288/j.11-2166/r.2008.03.041.

摘要

目的通过拆方研究方法

观察化痰活血方中化痰药和活血药对高脂血症模型大鼠肝脏过氧化物酶体增殖物激活受体α（PPARα）的影响

以明确化痰活血方中不同组分的调脂机理。方法Wistar大鼠50只

随机分为空白组、模型组、全方组、化痰药组、活血药组等5组

采用高脂饲料建立大鼠高脂血症模型。连续灌胃给药30天后

应用RT-PCR法测定各组大鼠肝PPARα mRNA水平。结果模型组大鼠肝PPARα mRNA表达明显低于空白组

全方组和化痰药组大鼠肝PPARα mRNA水平明显高于模型组

而活血组大鼠肝PPARα mRNA水平和模型组比较差异无统计学意义。结论化痰药是化痰活血方中提高高脂血症模型大鼠肝PPARα mRNA水平的主要组分

方中活血药可能通过其他途径发挥治疗作用。

Abstract

Objective To observe the influence of the medicines for resolving phlegm and the medicines for promoting blood circulation on the peroxysome proliferators-activated receptor α （PPARα） in the liver of the hyperlipemia-modeled rats in order to make sure the effect of different components of the whole formula. Methods The 50 Wistar rats were randomized into 5 groups: blank group

model group

whole formula group

group taking the medicines for resolving phlegm

and group taking the medicines for promoting blood circulation. The rats except the blank group were modeled by giving high fat feed into stomach once a day . After 30 days

RT-PCR was adopted to determine the level of PPARα mRNA of each group. Results The level of PPARα mRNA of model group was apparently lower than that of blank group. Compared with the model group

the PPARα mRNA of the whole formula group and the group taking medicines for resolving phlegm increased evidently

but there was no significant difference between the group taking medicines for promoting blood circulation and the model group on the level of PPARα mRNA. Conclusion The medicines for resolving phlegm in the whole formula play the most important role in increasing PPARα mRNA in the liver of the hyperlipemia model rats

while the medicines for promoting blood circulation may affect through other ways.

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