Objective To observe the effect and machanism of Xiaogu Granule （Granules for treating tympanites） plus ultrafiltration and reinfusion of ascites on refractory ascites resulted from hepatocirrhosis. Methods The 100 cases of refractory ascites due to hepatocirrhosis were randomized into two groups

with 50 cases in each. Both groups were administered basic treatment + ultrafiltration and reinfusion of ascites. The experimented group was added Xiaogu Granule and the control groups was added placebo. Before treatment

3 and 6 months after treatment

the portal vein diameter （PVD）

splenic vein diameter （SVD）

blood flow quantity of portal vein （PVQ） and of splenic vein （SVQ）

and the level of serum alanine aminotransferase

total bilirubin

endotoxin

nitrous oxide （NO） and endothelin （ET） of the two groups were measured respectively. Results After treatment

all the indices of two groups showed that the effect of experimented group was obviously better than that of control group

the difference was significant （P<0.05 or P<0.01）. Conclusion Xiaogu Granule in combination with ultrafiltration and reinfusion of ascites has a good effect for refractory ascites of hepatocirrhosis

and the possible mechanism might be getting the NO and ET secretion reduced

the hemodynamics disorder corrected and the portal vein pressure lowered.