Effect of Reinforcing Qi,Replenishing Yin,Activating Blood and Removing Toxins on the Endothelial Injury of Vessels,Platelet Activation and Inflammatory Factor in Coronary Heart Disease Patients

ZHANG Zhen-xian1; JIANG Yan-fen2; FU De-yu1; et al.

doi:10.13288/j.11-2166/r.2008.04.033

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Effect of Reinforcing Qi,Replenishing Yin,Activating Blood and Removing Toxins on the Endothelial Injury of Vessels,Platelet Activation and Inflammatory Factor in Coronary Heart Disease Patients

更新时间：2021-11-17

- Effect of Reinforcing Qi,Replenishing Yin,Activating Blood and Removing Toxins on the Endothelial Injury of Vessels,Platelet Activation and Inflammatory Factor in Coronary Heart Disease Patients
- Journal of Traditional Chinese Medicine Issue 4, Pages: 317-319(2008)
- 作者机构：
  
  1. 上海中医药大学附属岳阳中西医结合医院内科
  2. 上海市中西医结合医院心内科
  3. 上海市普陀区中医医院中医内科上海市虹口区甘河路110号
  4. ,200437
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2008.04.033
  CLC： R259
- Published：2008
- 稿件说明：
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[1]张振贤,江艳芬,符德玉,吴丽丽,周婷.益气养阴、活血解毒法对冠心病患者血管内皮损伤、血小板活化及炎症因子的影响[J].中医杂志,2008(04):317-319.

ZHANG Zhen-xian1, JIANG Yan-fen2, FU De-yu1, et al. Effect of Reinforcing Qi,Replenishing Yin,Activating Blood and Removing Toxins on the Endothelial Injury of Vessels,Platelet Activation and Inflammatory Factor in Coronary Heart Disease Patients[J]. Journal of Traditional Chinese Medicine2008, (4): 317-319.
[1]张振贤,江艳芬,符德玉,吴丽丽,周婷.益气养阴、活血解毒法对冠心病患者血管内皮损伤、血小板活化及炎症因子的影响[J].中医杂志,2008(04):317-319. DOI： 10.13288/j.11-2166/r.2008.04.033.

ZHANG Zhen-xian1, JIANG Yan-fen2, FU De-yu1, et al. Effect of Reinforcing Qi,Replenishing Yin,Activating Blood and Removing Toxins on the Endothelial Injury of Vessels,Platelet Activation and Inflammatory Factor in Coronary Heart Disease Patients[J]. Journal of Traditional Chinese Medicine2008, (4): 317-319. DOI： 10.13288/j.11-2166/r.2008.04.033.

摘要

目的探讨益气养阴、解毒活血组方对冠心病患者血小板活化、内皮功能紊乱和炎症反应相关指标的影响。方法将86例冠心病患者随机分为益气养阴、活血解毒组（治疗1组）、益气养阴组（治疗2组）及对照组

观察患者治疗前后血浆中血管性假性血友病因子（vWF）、α颗粒膜蛋白140（GMP-140）、血清C反应蛋白（CRP）和肿瘤坏死因子α（TNF-α）、白细胞介素6（IL-6）含量变化。结果治疗后治疗1组vWF、GMP-140、CRP、TNF-α、IL-6含量均明显低于其他组（P<0.05）。结论益气养阴、解毒活血方治疗冠心病能起到改善其内皮细胞损伤、抑制血小板活化、抗动脉炎症反应、改善动脉硬化的作用。

Abstract

Objective To study the effect of prescriptions of reinforcing qi

replenishing yin

activating blood and removing toxins on the platelet activation

vessel endothelial disorders and inflammatory reactions in coronary heart disease patients.Methods The 86 patients were randomized into the group of reinforcing qi

replenishing yin

activating blood and removing toxins（treatment group 1）

the group of reinforcing qi and replenishing yin（treatment group 2）

and the control group.Before and after treatment

the level of plasma von willebrand factor（vWF）

alpha-granular membrane protein（α-GMP-140）

serum C-reactive protein（CRP）

tumor necrosis factor-α（TNF-α）and interleukin-6（IL-6）was measured respectively.Results After treatment

vWF

α GMP-140

CRP

TNF-α and IL-6 of treatment group 1 were significantly lowered than those of other groups（P<0.05）.Conclusion The prescriptions of reinforcing qi

replenishing yin

activating blood and removing toxins can obviously repair the endothelial injuries

inhibit the platelet activation

resist the arterial inflammatory reactions

and improve the arteriosclerosis.

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