Objective To study the effect and its mechanism of Modified Wenjing Decoction（Decoction for warming channels）on vasomotion in patients with menstrual disease of blood stasis due to cold accumulation.Methods The 50 patients of emmeniopathy with blood stasis due to cold accumulation were successively treated with Modified Wenjing Decoction for three menstrual cycles.The therapeutic effect and changes of nitrous oxide（NO）

endothelin（ET）

thromboxane B2（TXB2）

6 ketone prostaglandin F1α（6-keto-PGF1α）of menstrual blood

reproductive hormones estradiol（E2）and progesterone（P）before and after treatment were observed.Results Of the 50 patients

19（38.0%）were short-term cured

24（48.0%）effective

and 7（14.0%）ineffective.After treatment

the levels of menstrual blood ET and TXB2 were decreased significantly（P<0.05）

while NO

6-keto-PGF1α

and E2 were increased significantly（P<0.05）.Conclusion Modified Wenjing Decoction is effective in improving the reproductive hormones and vasomotion in the treatment of emmeniopathy of blood stasis due to cold accumulation.