Clinical Study on 38 Cases of Early Diabetic Nephropathy Treated by the Method of Reinforcing Kidney,Activating Blood and Removing Obstruction of Meridians

HUANG Yan-qin XU Yun-sheng

doi:10.13288/j.11-2166/r.2008.05.033

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Clinical Study on 38 Cases of Early Diabetic Nephropathy Treated by the Method of Reinforcing Kidney,Activating Blood and Removing Obstruction of Meridians

更新时间：2021-11-17

- Clinical Study on 38 Cases of Early Diabetic Nephropathy Treated by the Method of Reinforcing Kidney,Activating Blood and Removing Obstruction of Meridians
- Journal of Traditional Chinese Medicine Issue 5, Pages: 421-423(2008)
- 作者机构：
  
  1. 山东中医药大学附属医院内分泌科
  2. 山东中医药大学附属医院内分泌科山东省济南市文化西路42号
  3. ,250014
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2008.05.033
  CLC： R259
- Published：2008
- 稿件说明：
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[1]黄延芹,徐云生.补肾活血通络法治疗早期糖尿病肾病38例临床观察[J].中医杂志,2008(05):421-423.

HUANG Yan-qin XU Yun-sheng. Clinical Study on 38 Cases of Early Diabetic Nephropathy Treated by the Method of Reinforcing Kidney,Activating Blood and Removing Obstruction of Meridians[J]. Journal of Traditional Chinese Medicine2008, (5): 421-423.
[1]黄延芹,徐云生.补肾活血通络法治疗早期糖尿病肾病38例临床观察[J].中医杂志,2008(05):421-423. DOI： 10.13288/j.11-2166/r.2008.05.033.

HUANG Yan-qin XU Yun-sheng. Clinical Study on 38 Cases of Early Diabetic Nephropathy Treated by the Method of Reinforcing Kidney,Activating Blood and Removing Obstruction of Meridians[J]. Journal of Traditional Chinese Medicine2008, (5): 421-423. DOI： 10.13288/j.11-2166/r.2008.05.033.

摘要

目的观察以补肾活血通络法为治则组成的糖络通汤剂对早期糖尿病肾病（DN）的临床疗效。方法68例DN患者随机分为两组

两组均采用常规糖尿病基础治疗

治疗组（38例）加服糖络通水煎剂

对照组（30例）加服氯沙坦钾

观察治疗前后临床症状、体征和实验室检查指标的变化。结果治疗组综合疗效总有效率为89.47%

对照组为60.00%

组间比较差异有统计学意义（P

0.01）;中医单项症状、体征改善总有效率差异显著（P

0.05）;在降低尿β

微球蛋白、血浆内皮素、一氧化氮方面都有较好的疗效

组间比较差异有统计学意义（P

0.05）。结论糖络通治疗早期DN疗效肯定

表明补肾活血通络法对早期DN具有良好防治作用。

Abstract

Objective To observe the effect of Tangluotong Decoction（Decoctions of removing obstruction of meridians for treating diabetes）based on the principle of reinforcing kidney

activating blood and removing obstruction of meridians on the early diabetic nephropathy（DN）patients.Methods Totally 68 DN patients were randomized into two groups.In addition to the routine treatment for diabetes

the treatment group（38 patients）was administered Tangluotong Decoction while the control group（30 patients）was giv- en Lossartan Potassium Tablets.The clinical symptoms and signs and lab indices before and after treatment were observed.Results The comprehensive total effective rate of the treatment group was 89.47% while that of control group was 60.00%

the difference was significant（P

0.01）.The difference of total effective rate of single symptoms in Chinese medicine between two groups were also sig- nificant（P

0.05）.The effect of Tangluotong Decoction was also good in decreasing urineβ

microglobulin（β

-MG）

plasma endothe- lin（ET）and nitrous oxide（NO）

and the difference between two groups was significant（P

0.05）.Conclusion Tangluotong De- coction has definite effect on early DN

indicating that the principle of reinforcing kidney

activating blood and removing obstruction of meridians functions well for it.

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