Objective To study the effect of Haikun Shenxi Capsule（HSC）on endothelin-1（ET-1）and mRNA expression of rats with adriamyein-induced nephrosis and proliferation of glomerular mesangial cells（GMCs）cultured in vitro.Methods The rats were randomized into 6 groups

normal group

sham operation group

model group

benazepril group

HSC low-and high-dose groups.Ten weeks after treatment

ET-1 and mRNA expression were measured with immunohistochemical and hybridization in situ method.Tak- ing the Benazepril group as the control group

the proliferation of GMCs was detected with MTT method.Results In the model group

ET-1 and mRNA expression presented a strong positive

compared with which

that of the HSC low-and high-dose groups was remarkably reduced（P<0.05）

and the effect of high-dose group was better as the proliferation of GMCs was remarkably suppressed. Conclusion HSC reduces remarkably ET-1 and mRNA expression in kidney tissue of rats with adriamycin-indueed nephrosis and de- creases the proliferation of GMCs

slowing down the development of renal failure.