Clinical Observation on 30 Cases of Henoch-Schonlein Purpura Nephritis Treated with Danshao Granule Ⅱ

KONG Fei1; SUN Yi-qiu2; FAN Zhong-min3; et al.

doi:10.13288/j.11-2166/r.2008.06.015

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Clinical Observation on 30 Cases of Henoch-Schonlein Purpura Nephritis Treated with Danshao Granule Ⅱ

更新时间：2021-11-17

- Clinical Observation on 30 Cases of Henoch-Schonlein Purpura Nephritis Treated with Danshao Granule Ⅱ
- Journal of Traditional Chinese Medicine Issue 6, Pages: 517-519(2008)
- 作者机构：
  
  1. 南京中医药大学
  2. 江苏省中医院
  3. 南京军区南京总医院儿科
  4. 江苏省中医院 2005级中医儿科专业硕士研究生江苏省南京市汉中路282号
  5. ,210029
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2008.06.015
  CLC： R277.5
- Published：2008
- 稿件说明：
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[1]孔飞,孙轶秋,樊忠民,吴波,高远赋,张永春,李辉,袁斌.丹芍颗粒Ⅱ号治疗过敏性紫癜性肾炎30例临床观察[J].中医杂志,2008(06):517-519.

KONG Fei1, SUN Yi-qiu2, FAN Zhong-min3, et al. Clinical Observation on 30 Cases of Henoch-Schonlein Purpura Nephritis Treated with Danshao Granule Ⅱ[J]. Journal of Traditional Chinese Medicine2008, (6): 517-519.
[1]孔飞,孙轶秋,樊忠民,吴波,高远赋,张永春,李辉,袁斌.丹芍颗粒Ⅱ号治疗过敏性紫癜性肾炎30例临床观察[J].中医杂志,2008(06):517-519. DOI： 10.13288/j.11-2166/r.2008.06.015.

KONG Fei1, SUN Yi-qiu2, FAN Zhong-min3, et al. Clinical Observation on 30 Cases of Henoch-Schonlein Purpura Nephritis Treated with Danshao Granule Ⅱ[J]. Journal of Traditional Chinese Medicine2008, (6): 517-519. DOI： 10.13288/j.11-2166/r.2008.06.015.

摘要

目的观察丹芍颗粒Ⅱ号治疗过敏性紫癜性肾炎的临床疗效。方法将55例过敏性紫癜性肾炎患儿随机分为两组。治疗组30例

给予丹芍颗粒号和雷公藤治疗;对照组25例

给予强的松和雷公藤治疗

疗程均为2个月

观察两组患儿治疗前后24小时尿蛋白、尿红细胞、尿N-乙酰-β-D-氨基葡萄糖酐酶（NAG）及T淋巴细胞亚群的变化。结果治疗组完全缓解率46.7%

对照组完全缓解率28.0%

差异有统计学意义（P<0.05）。治疗组在降低血尿、蛋白尿和尿NAG酶方面优于对照组（均P<0.05）。两组治疗前后CD3+和CD8+差异无统计学意义（P>0.05）

而两组治疗后CD19+显著降低

CD4+、CD16/56+显著升高（均P<0.05）

治疗组优于对照组（P<0.05）。结论丹芍颗粒Ⅱ号治疗过敏性紫癜性肾炎有较好临床疗效。

Abstract

Objective To observe the effect of Danshao Granule Ⅱ on children Henoch-Schonlein purpura nephritis（HSPN）.Methods The 55 children with HSPN were divided into treatment group（30 cases） treated with Danshao Granule Ⅱ and Wilfordii Multiglycoside Tablet

and control group（25 cases） treated with prednisone and Wilfordii Multiglycoside Tablet.The changes of both groups in urinary protein

red blood cell

N-acetyl-β-glucosaminidase（NAG） and T cell subsets were observed after 2-month treatment.Results The complete remission（CR） rate of the treatment group was 46.7%

while that of the control group was 28.0%

the difference was significant（P<0.05）.After 2-month treatment

the treatment group was more remarkably improved than the control group（both P<0.05） in urinary protein

RBC and NAG.CD19+ of both groups was remarkably decreased

while CD4+ and CD16/56+ remarkably increased（both P<0.05）

the treatment group being better than the control group（P<0.05）.Conclusion Danshao Granule Ⅱ has a good therapeutic effect on HSPN children.

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