Objective To explore the effect and mechanism of Wuwei Dilong Decoction（Schisandra Fuit and Earthworm Decoction） on asthma.Methods The guinea pigs for experiment were sensitized with ovalbumin（OVA） to establish asthmatic animal models.Fifteen days later

the guinea pigs were administered Wuwei Dilong Decoction once a day for 8 days in succession.Blood sample was taken for testing the total leucocytes

eosinophil（EOS）

lymphocytes

interferon-γ（IFN-γ） and leukotriene B4（LTB4）.Results In the asthma model group

the total leucocytes

EOS and lymphocytes were all increased

comparing with the Wuwei Dilong Decoction groups of different dosages

the difference was significant（P<0.01 or P<0.05）.The serum LTB4 of asthma model group were obviously increased and IFN-γ decreased.Upon administration of Wuwei Dilong Decoction

the large

medium and small dosages could make LTB4 decreased（P<0.01） while IFN-γ increased.Conclusion Wuwei Dilong Decoction can inhibit the infiltration and diffusion of inflammatory cells in asthma

functioning to regulate LTB4 and IFN-γ

which might be one of the important mechanism of Wuwei Dilong Decoction in relieving asthma.