Effect of Chinese Medicine Containing Serum on Cell Cycle of Drug-resistanct Lung Cancer Cells A549/DDP

CAO Yong; ZHONG An-pu; CHEN Lu; et al.

doi:10.13288/j.11-2166/r.2008.06.041

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Effect of Chinese Medicine Containing Serum on Cell Cycle of Drug-resistanct Lung Cancer Cells A549/DDP

更新时间：2021-11-17

- Effect of Chinese Medicine Containing Serum on Cell Cycle of Drug-resistanct Lung Cancer Cells A549/DDP
- Journal of Traditional Chinese Medicine Issue 6, Pages: 546-549(2008)
- 作者机构：
  
  1. 暨南大学医学院中医系
  2. 暨南大学医学院中医系广东省广州市黄埔大道西601号
  3. ,510632
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2008.06.041
  CLC： R285.5
- Published：2008
- 稿件说明：
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[1]曹勇,钟安朴,陈璐,李亮,许林利.补肾化瘀解毒复方含药血清对肺癌A549/DDP耐药细胞周期的影响[J].中医杂志,2008(06):546-549.

CAO Yong, ZHONG An-pu, CHEN Lu, et al. Effect of Chinese Medicine Containing Serum on Cell Cycle of Drug-resistanct Lung Cancer Cells A549/DDP[J]. Journal of Traditional Chinese Medicine2008, (6): 546-549.
[1]曹勇,钟安朴,陈璐,李亮,许林利.补肾化瘀解毒复方含药血清对肺癌A549/DDP耐药细胞周期的影响[J].中医杂志,2008(06):546-549. DOI： 10.13288/j.11-2166/r.2008.06.041.

CAO Yong, ZHONG An-pu, CHEN Lu, et al. Effect of Chinese Medicine Containing Serum on Cell Cycle of Drug-resistanct Lung Cancer Cells A549/DDP[J]. Journal of Traditional Chinese Medicine2008, (6): 546-549. DOI： 10.13288/j.11-2166/r.2008.06.041.

摘要

目的探讨补肾化瘀解毒复方含药血清对肺癌耐药细胞周期的影响。方法采用血清药理学及流式细胞法

分析补肾化瘀解毒复方含药血清分别与顺铂（DDP）和维拉帕米（VRP）合用后A549/DDP耐药细胞周期的变化。结果补肾化瘀解毒复方含药血清均能明显增加A549/DDP耐药细胞G0/G1期细胞数

减少S期和G2/M期的细胞比例（P<0.05）。结论补肾化瘀解毒复方含药血清能使A549/DDP耐药细胞阻滞于G0/G1期

协同增强DDP和VRP阻止A549/DDP耐药细胞DNA的合成

抑制肺癌耐药细胞的分裂增殖。

Abstract

Objective To explore the effect of serum containing Recipe of Reinforcing Kidney

Dissolving Stasis and Removing Toxins（RRDR） on the cell cycle of drug-resistanct lung cancer cells.Methods Serum pharmacology and flow cytometry methods were used to analyze the effect of combination of medicine containing serum with cisplatin（DDP） and verapamil（VRP） respectively on the cell cycle of drug-resistanct lung cancer cells A549/DDP.Results The medicine containing serum could significantly increase the A549/DDP cells in G0/G1 phase and lower the cell ratio of S and G2/M phases（P<0.05）.Conclusion The Serum containing RRDR is able to inhibit the growth of A549/DDP drug-resistanct cells in the G0/G1 phase

and enhance DDP and VRP to prevent A549/DDP cells from DNA synthesis

and inhibit the division proliferation of drug-resistant lung cancer cells.

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