Study on the Mechanism of Jianwei Yuyang Granule in Protection of Gastric Mucosa against Peptic Ulcer

HUANG Guo-Dong1; HUANG Yuan-Hua2; HUANG Dao-Fu2; et al.

doi:10.13288/j.11-2166/r.2008.07.014

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Study on the Mechanism of Jianwei Yuyang Granule in Protection of Gastric Mucosa against Peptic Ulcer

更新时间：2021-11-17

- Study on the Mechanism of Jianwei Yuyang Granule in Protection of Gastric Mucosa against Peptic Ulcer
- Journal of Traditional Chinese Medicine Issue 7, Pages: 614-617(2008)
- 作者机构：
  
  1. 中南大学湘雅医院中西医结合研究所
  2. 湖南中医药大学附属衡阳医院
  3. 湖南省人民医院湖南省长沙市湘雅路87号
  4. ,410008
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2008.07.014
  CLC： R259
- Published：2008
- 稿件说明：
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[1]黄国栋,黄媛华,黄道富,李家邦,肖美珍,唐丽君.健胃愈疡颗粒保护消化性溃疡胃黏膜的机制探讨[J].中医杂志,2008(07):614-617.

HUANG Guo-Dong1, HUANG Yuan-Hua2, HUANG Dao-Fu2, et al. Study on the Mechanism of Jianwei Yuyang Granule in Protection of Gastric Mucosa against Peptic Ulcer[J]. Journal of Traditional Chinese Medicine2008, (7): 614-617.
[1]黄国栋,黄媛华,黄道富,李家邦,肖美珍,唐丽君.健胃愈疡颗粒保护消化性溃疡胃黏膜的机制探讨[J].中医杂志,2008(07):614-617. DOI： 10.13288/j.11-2166/r.2008.07.014.

HUANG Guo-Dong1, HUANG Yuan-Hua2, HUANG Dao-Fu2, et al. Study on the Mechanism of Jianwei Yuyang Granule in Protection of Gastric Mucosa against Peptic Ulcer[J]. Journal of Traditional Chinese Medicine2008, (7): 614-617. DOI： 10.13288/j.11-2166/r.2008.07.014.

摘要

目的观察健胃愈疡颗粒对溃疡黏膜乳癌相关肽（PS2）和解痉多肽（SP）表达的变化

并分析其可能的作用机制。方法选取消化性溃疡（PU）患者72例

随机分为两组

其中健胃愈疡颗粒组（治疗组）和雷尼替丁组（对照组）各36例

另设正常组12例。胃黏膜组织用免疫组化检测SP的表达

Western印迹检测PS2表达的变化

并同时检测氨基己糖及磷脂含量。结果治疗组氨基己糖、磷脂含量和PS2、SP的表达有直线相关关系（P<0.01）。结论健胃愈疡颗粒通过提高PS2和SP的表达

通过影响胃黏膜疏水性

最终防止溃疡的产生和复发。

Abstract

Objective To observe the influence of Jianwei Yuyang Granule（Granule for strengthening the stomach to treat ulcer）on the expressions of the breast cancer-associated peptide（PS2）and spasmolytic polypeptide（SP）of ulcerated gastric mucosa in order to analyze its potential mechanism.Methods The 72 patients of gastric ulcer（PU）were randomized into Jianwei Yuyang Granule group（treatment group）and Ranitidine group（control group）with 36 in each.The normal group was established with 12 people in it.The immunohistochemical determination of SP expression

the determination of PS2 expression by Western blotting

and the determination of contents of aninohexose and phosphatide were carried out.Results In the treatment group

a linear correlation was existing between the contents of aninohexose and phosphatide and the expression of SP and PS2（P<0.01）.Conclusion Jianwei Yuyang Granule prevents the occurrence and relapse of ulceration by increasing the expression of PS2 and SP and by its influence on hydrophobicity of gastric mucosa.

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