Objective To observe the relationship between the brain total cholesterol and the dementia of senescence accelerated mice-prone 10（SAMP10）and explore the mechanism of acupuncture method "reinforcing qi and regulating blood

strengthening the root and build up the strong constitution" in improving the dementia.Methods The Senescence-accelerated mice-resistant 1（SAMR1）control group

SAMP10 control group

SAMP10 acupuncture group

and SAMP10 non-point group were established.The Morris water maze was used to test the learning ability and memory of mice of all groups

and the Folch and colorimetric methods were applied to observe the contents of their brain total cholesterol.Results Compared with the SAMR1 control group

the mice of SAMP10 control group had significant impairment in learning ability and memory and their brain total cholesterol was evidently increased

the difference was significant（P<0.05）.And the difference in the SAMP10 acupuncture group in decreasing the brain total cholesterol and improving the learning ability and memory was also significant in comparing with the SAMP10 control group（P<0.05）.Conclusion Regulating the stability of brain cholesterol may be one of the mechanisms of acupuncture in "reinforcing qi and regulating blood

strengthening the root and build up the strong constitution" to treat dementia.