Objective To explore the relevance of TCM syndromes of irritable bowel syndrome（IBS） with the intestinal cholecystokinin（CCK）

c-fos and substance P.Methods The symptom check list（SCL-90） was adopted to examine the IBS patients and the persons in the normal control group to evaluate their psychological status

and the CCK

c-fos and substance P of them were measured with the immunohistochemical method for analysis.Results The IBS patients were obviously combative and with anxiety and depression;the significant difference existed in those who were of liver-related or non liver-related on anxiety and depression（P<0.01）;and there showed a significant difference between the excess and deficiency syndromes in substance P

c-fos of average positive area and optical density（OD） of ileocecal region（P<0.05）.Conclusion The TCM syndromes of IBS patients have relevance with the expression of c-fos and substance P of intestinal mucosa.