Objective To study the expressions of epithelial symbol factors including E-cadherin

α-catenin

and β-catenin related to epithelial-mesenchymal transition（EMT） in C57 mice Lewis lung cancer and its mRNA expression affected by Feiyanning Decoction（Decoction for lung cancer）.Methods The Real-Time PCR method was adopted to observe the E-cadherin

α-catenin

β-catenin mRNA expression of C57 mice with transplanted tumor in the right armpit and distal metastases and the affection of Feiyanning Decoction on the expression.Results The lung transplanted rate in the Feiyanning group was clearly lower than that in the model group（P<0.01）.In the transplanted tumor tissues of all groups

the expression of E-cadherin

α-catenin and β-catenin of Feiyanning group and chemotherapy positive control group was all higher than that of model group（P<0.01）.As in the lung tissues of all groups

the expression of E-cadherin

α-catenin and β-catenin of model group was clearly lower than that of normal lung tissues（P<0.05）

but with treatment of Feiyanning Decoction

these 3 symbol factors were all clearly increased（P<0.05 or P<0.01）.Conclusion Feiyanning Decoction functions to up-regulate the epithelial symbol factors

playing a role in anti-metastasis of tumors maybe through inhibiting the occurrence of EMT.