Objective To study the therapeutic effect of Guanxin Ⅱ（Prescription for coronary heart disease）on the experimental myocardial infarction of rats and to observe the correlation among the vascular endothelial growth factor（VEGF）

basic fibroblast growth factor（bFGF）and B natriuretic peptide（BNP）after the occurrence of myocardial infarction.Methods Of the 36 healthy male rats

9 were put into the sham operation group.Of the 27 male rats with coronary artery ligation to establish the myocardial infarction models

9 were put into the model group

9 put into the Guanxin Ⅱ low dosage group（3g/kg）

and 9 put into the Guanxin Ⅱ high dosage group（9g/kg）.Fifteen days after the operation

N-BT staining was adopted to determine the area of myocardial infarction

enzyme-linked immunosorbent assay（ELISA）used to determine VEGF

bFGF and BNP

and Bivariate Correlation method was used to analyze the correlation of VEGF

bFGF and BNP.Results With 15 days’ medication

the area of myocardial infarction in the Guanxin Ⅱ high dosage group was reduced

BNP decreased and VEGF increased

showing a statistical significance in comparing with the model group（P<0.01 or P<0.05）.Conclusion Guanxin Ⅱ can reduce the area of myocardial infarction.It treats myocardial infarction through regulating VEGF and bFGF.And VEGF

bFGF and BNP are correlated with each other after occurrence of myocardial infarction.