Objective To study the anti-neoplastic effect of Xuezhikang （Regulate blood-fat） Capsule in vitro and its influence on the chemotherapeutic drug 5 Fluorouracil （5-Fu）.Methods Using MTT method to measure the inhibition rate of Xuezhikang Capsule used simply

5-Fu used simply and Xuezhikang Capsule with 5-Fu together on HepG2

MCF-7 and HL-60 cells.Results The inhibitory action of Xuezhikang Capsule（2.56

0.64

0.16

0.04

0.01 mg/ml） on HepG2

MCF-7 and HL-60 cells was dose-dependent and the IC50 was 14.057

19.859 and 27.771mg/ml respectively.The inhibition ratio of five different doses of Xuezhikang Capsule（0.64

0.16

0.04

0.01

0.0025 mg/ml） with 5-Fu （0.24mg/ml） together all remarkably higher than that of 5-Fu used simply.Conclusion Xuezhikang Capsule has a significant anti-cancer effect in vitro and can enhance remarkably the anti-neoplastic effect of 5-Fu.