Influence of Tanwei Capsule on Interleukin 4 and Transforming Growth Factor-β<sub>1</sub> of Mice with Experimental Autoimmune Myasthenia Gravis

JIN Shuo-guo; LIU Fu-you; CHEN Wei-yin; et al.

doi:10.13288/j.11-2166/r.2008.11.045

您当前的位置：

首页 >

文章列表页 >

Influence of Tanwei Capsule on Interleukin 4 and Transforming Growth Factor-β₁ of Mice with Experimental Autoimmune Myasthenia Gravis

更新时间：2021-11-17

- Influence of Tanwei Capsule on Interleukin 4 and Transforming Growth Factor-β₁ of Mice with Experimental Autoimmune Myasthenia Gravis
- Journal of Traditional Chinese Medicine Issue 11, Pages: 1028-1030(2008)
- 作者机构：
  
  1. 成都中医药大学附属医院神经内科
  2. 成都市第二人民医院康复科
  3. 四川大学华西医院中西医结合科
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2008.11.045
  CLC： R285.5
- Published：2008
- 稿件说明：
移动端阅览
[1]金硕果,刘福友,陈卫银,冷卫军,冉宁晶,周雨颗.瘫痿胶囊对自身免疫性重症肌无力小鼠血清白细胞介素4及转化生长因子β_1的影响[J].中医杂志,2008(11):1028-1030.

JIN Shuo-guo, LIU Fu-you, CHEN Wei-yin, et al. Influence of Tanwei Capsule on Interleukin 4 and Transforming Growth Factor-β₁ of Mice with Experimental Autoimmune Myasthenia Gravis[J]. Journal of Traditional Chinese Medicine2008, (11): 1028-1030. DOI: 10.13288/j.11-2166/r.2008.11.045.
[1]金硕果,刘福友,陈卫银,冷卫军,冉宁晶,周雨颗.瘫痿胶囊对自身免疫性重症肌无力小鼠血清白细胞介素4及转化生长因子β_1的影响[J].中医杂志,2008(11):1028-1030. DOI： 10.13288/j.11-2166/r.2008.11.045.

JIN Shuo-guo, LIU Fu-you, CHEN Wei-yin, et al. Influence of Tanwei Capsule on Interleukin 4 and Transforming Growth Factor-β₁ of Mice with Experimental Autoimmune Myasthenia Gravis[J]. Journal of Traditional Chinese Medicine2008, (11): 1028-1030. DOI: 10.13288/j.11-2166/r.2008.11.045. DOI：

摘要

目的观察瘫痿胶囊对实验性自身免疫性重症肌无力（EAMG）的作用机制。方法以乙酰胆碱受体α1肽（AChRα1肽）多点注射法制备EAMG模型小鼠

将造模成功的58只健康雌性C57BL/6小鼠随机分为7组:模型组

瘫痿胶囊低、中、高剂量组

强的松组及正常组、佐剂组

观察其症状变化

检测其血清乙酰胆碱受体抗体（AChR-Ab）、转化生长因子β1（TGF-β1）、白介素4（IL-4）水平。结果4周后

与模型组比较

瘫痿胶囊高中剂量组及强的松组临床症状评分减少（P<0.01）

AChR-Ab降低（P<0.01）

TGF-β1升高（P<0.05）

IL-4降低（P<0.05）。结论瘫痿胶囊治疗EAMG的机制可能是通过升高外周血TGF-β1水平、降低IL-4

抑制AChR-Ab的产生

从而改善临床症状。

Abstract

Objective To explore the mechanism of Tanwei Capsule （Capsule for paralysis） on the experimental autoimmune myasthenia gravis （EAMG）.Methods The EAMG mice model were made with AChRα1 injection.The 58 healthy female C57BL/6 mice models were randomized into 7 groups:model group

Tanwei Capsule low

medium and high dosage groups

prednisone group

normal group

and adjuvant group.Symptoms

serum acetylcholine receptor antibody（AchR-Ab）

transforming growth factor-β1（TGF-β1） and Interleukin-4（IL-4） were observed.Results Four weeks later

compared with the model group

the scores of Tanwei Capsule high and medium dosage groups and prednisone group were decreased （P<0.01）

AchR-Ab decreased （P<0.01）

TGF-β1 increased （P<0.05）

and IL-4 decreased （P<0.05）.Conclusion The mechanism of Tanwei Capsule relieving clinical symptoms of EAMG is possibly through increasing TGF-β1

decreasing IL-4

and inhibiting the production of AchR-Ab.

关键词

Keywords

references

查看原文

Views

175

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Effects of Serum Containing Fugan Huaxian Decoction（扶肝化纤汤） on TGF-β1 Induced HSC-T6 Proliferation and TGF-β 1/Smad Signaling Pathway

Effect of Artemisia Argyi Extracting Solution Contained Rat Serum on Eexpression of Transforming Growth Factor-β1 and Protein Smads in Hepatic Stellate Cells

A Preliminary Discussion on the Method of Regulating Qi and Calming the Mind

Exploring the Comorbidity Mechanism，Prevention and Treatment Strategies of Rheumatoid Arthritis with Coronary Atherosclerotic Heart Disease Based on Collateral Disease Theory

Differentiation and Treatment of Small Cell Lung Cancer from the Perspective of "Internal Wind in Hidden Circulation"

Related Author

XIAO Zhenghua

ZOU Yan

YANG Hui

TAN Qianren

CUI Junsong

HU Fang

XIONG Zhenfang1

WANG Weimin1

Related Institution

The Second Clinical Medical College of Guizhou University of Traditional Chinese Medicine

Guizhou University of Traditional Chinese Medicine

Doctroal student,Hubei University of Chinese Medicine

TCM Hospital of Hubei Province

Address：No.16, Nanxiao street, Dongzhimen, Dongcheng District, Beijing Postal code：100700
Tel：010-64035632 Email：jtcmcn@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备09064830号-19 京公网安备11010102007558号
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰

Influence of Tanwei Capsule on Interleukin 4 and Transforming Growth Factor-β1 of Mice with Experimental Autoimmune Myasthenia Gravis

DOI：10.13288/j.11-2166/r.2008.11.045

摘要

Abstract

关键词

Keywords

references

Influence of Tanwei Capsule on Interleukin 4 and Transforming Growth Factor-β₁ of Mice with Experimental Autoimmune Myasthenia Gravis