Objective To study the effect of Immature Bitter Orange（Zhishi

Fructus Aurantii Immaturus） Capsule on the risk factors of pre-thrombotic state in acute coronary syndrome（ACS） patients.Methods The 67 ACS patients were randomly divided into Fructus Aurantii Immaturus treatment group（34 cases） and routine therapy group（33 cases）

and 30 healthy people patients were chosen as control group.The risk factors of pre-thrombotic state such as platelet aggregation

erythrocyte deformation index

red blood cell（RBC） aggregation

platelet surface P-selectin（CD62P）

D-dimer

serum nitric Oxide（NO）

plasma endothelin-1（ET-1）

and Oxidized low density lipoprotein（Ox-LDL） were measured before and three weeks after treatment respectively.Results Compared with the control group

the levels of RBC aggregation

D-dimer

CD62P

ET-1 and Ox-LDL were obviously higher

while NO was lower in ACS patients.After treatment

NO of treatment group and routine therapy group was obviously higher

while platelet aggregation

RBC aggregation

CD62P

D-dimer

ET-1

and Ox-LDL were obviously lower（P<0.05 or P<0.01）.Compared with the routine therapy group

NO of treatment group was obviously higher

while RBC aggregation

D-dimer

ET-1

and Ox-LDL were obviously lower（P<0.05 or P<0.01）.Conclusion For the ACS patients

the Immature Bitter Orange Capsule functions to improve endothelial cells as well as lower the platelet aggregation and RBC aggregation to strengthen antiOxidation.