Objective To study the therapeutic effect of Yangyin（Replenishing Yin） Huoxue（Activating blood） Jiedu（Clearing toxic） therapy on coronary heart disease（CHD） and on endothelial function.Methods Totally 60 coronary heart disease patients were randomized into treatment and control groups

30 in each.The control group received routine treatment including β receptor blocker

calcium channel blocker（CCB） and long-acting nitrate.The treatment group received the routine treatment and Yangyin Huoxue Jiedu therapy.The effect was observed and treadmill exercise test（TET） was performed before and after treatment.Results In the treatment group

the frequency of chest pain was greatly lowered than that in the control group

the levels of serum C-reactive protein（CRP）

interleukin-6（IL-6）

endothelin-1（ET-1） and endothelin（ET） /nitric oxide（NO） were significantly decreased

the level of NO was tremendously increased

the time in TET was obviously prolonged（P<0.05 or P<0.01）.In decreasing CRP

IL-6 and ET-1

increasing NO

and improving the storage of heart function

the effect of treatment group was also better than that of the control group（P<0.05 or P<0.01）.Conclusion Yangyin Huoxue Jiedu therapy is effective in relieving endothelial inflammatory reactions in coronary and improving the endothelial function and storage of heart function.