Clinical Observation on the Effect of Shugan Lidan Paidu Decoction on 38 Patients with Wilson Disease

WANG Dianhua; CHEN Jinliang; YUAN Xueshan

doi:10.13288/j.11-2166/r.2009.02.016

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Clinical Observation on the Effect of Shugan Lidan Paidu Decoction on 38 Patients with Wilson Disease

更新时间：2021-11-17

- Clinical Observation on the Effect of Shugan Lidan Paidu Decoction on 38 Patients with Wilson Disease
- Journal of Traditional Chinese Medicine Vol. 50, Issue 2, Pages: 142-144(2009)
- 作者机构：
  
  河北医科大学附属以岭医院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2009.02.016
  CLC： R277.7
- Published：2009
- 稿件说明：
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[1]王殿华,陈金亮,袁学山.疏肝利胆排毒汤治疗肝豆状核变性38例临床观察[J].中医杂志,2009,50(02):142-144.

WANG Dianhua, CHEN Jinliang, YUAN Xueshan. Clinical Observation on the Effect of Shugan Lidan Paidu Decoction on 38 Patients with Wilson Disease[J]. Journal of Traditional Chinese Medicine2009, 50(2): 142-144.
[1]王殿华,陈金亮,袁学山.疏肝利胆排毒汤治疗肝豆状核变性38例临床观察[J].中医杂志,2009,50(02):142-144. DOI： 10.13288/j.11-2166/r.2009.02.016.

WANG Dianhua, CHEN Jinliang, YUAN Xueshan. Clinical Observation on the Effect of Shugan Lidan Paidu Decoction on 38 Patients with Wilson Disease[J]. Journal of Traditional Chinese Medicine2009, 50(2): 142-144. DOI： 10.13288/j.11-2166/r.2009.02.016.

摘要

目的观察疏肝利胆排毒汤治疗肝豆状核变性（WD）的临床疗效。方法58例WD患者随机分为治疗组（38例）和对照组（20例）

治疗组服用中药疏肝利胆排毒汤治疗

对照组服用青霉胺片治疗

30天为1个疗程。3个疗程后观察两组疗效及尿铜、角膜色素环（K-F环）、血清铜、血清铜蓝蛋白、血清铜氧化酶的变化。结果治疗组总有效率为73.68%

对照组为70.00%

两组比较差异无统计学意义（P>0.05）

但治疗组无任何不良反应

且相关生化指标均有不同程度的变化。结论中药疏肝利胆排毒汤治疗肝豆状核变性安全有效

有可能改善体内铜浊毒邪运转机制。

Abstract

Objective To observe the effect of Shugan Lidan Paidu Decoction（Decoction for regulating liver and gall bladder and removing toxin） on Wilson disease（WD）.Methods The 50 WD patients were randomized into the treatment group（38 cases） and control group（20 cases）.The treatment group was administered with Chinese medicines functioning to regulate liver and gall bladder and remove toxin while the control group was given Penicillamine

30 days as one course.After 3 courses of treatment

the effect of both groups and the changes in urinary copper

Kayser-Fleischer（K-F） ring

serum copper

serum ceruloplasmin（CP） and serum copper oxidase were observed.Results The total effective rate of treatment group and control group was 73.68% and 70.00% respectively

without significant difference（P>0.05）

but there was no side effect in the treatment group and changes in the related biochemical indices were found as well.Conclusion Shugan Lidan Paidu Decoction is safe and effective in the treatment of WD.It possibly improves the transportation and transformation mechanism of copper-toxin.

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