Objective To study the effect of Xuejie Jiawei Granule on hysteromyoma of eleven-month-old natural aging mice models with estrogen load.Methods The eleven-month-old mice hysteromyoma models established by intramuscular injection of estrogen were randomized into Xuejie Jiawei Granule group

Mifepristone control group

Guizhi Fuling Capsule control group and model control group

10 in each group.Another 10 healthy mice were of the normal control group. Uterus coefficients

muscle thickness

contents of E2 and P in blood serum

expressions of estrogen receptor（ER） and progesterone receptor（PR）

expressions of insulin-like growth factor-I（IGF-I）

and expressions of vascular endothelia growth factor（VEGF） were observed.Results Xuejie Jiawei Granule obviously reduced uterus coefficients

decreased contents of E2 and P in blood serum

and inhibited expressions of ER

PR

IGF-I

and VEGF of uterine tissues of mice models.Conclusion Xuejie Jiawei Granule inhibits obviously the growth of hysteromyoma of mice models with estrogen load.