Application of Nuclear Magnetic Resonance Metabonomic Technique in the Study on Physiological Kidney Deficiency Syndrome

WU Bin1; SHEN Ziyin1; WANG Lili2; et al.

doi:10.13288/j.11-2166/r.2009.04.010

您当前的位置：

首页 >

文章列表页 >

Application of Nuclear Magnetic Resonance Metabonomic Technique in the Study on Physiological Kidney Deficiency Syndrome

更新时间：2021-11-17

- Application of Nuclear Magnetic Resonance Metabonomic Technique in the Study on Physiological Kidney Deficiency Syndrome
- Journal of Traditional Chinese Medicine Vol. 50, Issue 4, Pages: 338-342(2009)
- 作者机构：
  
  1. 复旦大学附属华山医院中西医结合研究所
  2. 浙江中医药大学药学院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2009.04.010
  CLC： R256.5
- Published：2009
- 稿件说明：
移动端阅览
[1]吴斌,沈自尹,王丽丽,黄建华,张新民,刘小雨,夏世金.应用核磁共振代谢组技术研究生理性肾虚证[J].中医杂志,2009,50(04):338-342.

WU Bin1, SHEN Ziyin1, WANG Lili2, et al. Application of Nuclear Magnetic Resonance Metabonomic Technique in the Study on Physiological Kidney Deficiency Syndrome[J]. Journal of Traditional Chinese Medicine2009, 50(4): 338-342.
[1]吴斌,沈自尹,王丽丽,黄建华,张新民,刘小雨,夏世金.应用核磁共振代谢组技术研究生理性肾虚证[J].中医杂志,2009,50(04):338-342. DOI： 10.13288/j.11-2166/r.2009.04.010.

WU Bin1, SHEN Ziyin1, WANG Lili2, et al. Application of Nuclear Magnetic Resonance Metabonomic Technique in the Study on Physiological Kidney Deficiency Syndrome[J]. Journal of Traditional Chinese Medicine2009, 50(4): 338-342. DOI： 10.13288/j.11-2166/r.2009.04.010.

摘要

目的观察生理性肾虚过程中尿液代谢物的特征性变化

以及补肾中药淫羊藿总黄酮（EF）的干预作用。方法收集4、10、18、24月龄组和EF干预组SD大鼠的尿液进行1H核磁共振检测

分别采用T2检验和趋势过滤法筛选生理性肾虚证的特征性代谢物

同时观察EF对这些代谢物的影响。结果筛选了34个与生理性肾虚证密切相关的谱峰

并鉴定了13个代谢物;发现生理性肾虚进程中存在明显的代谢差异

EF能明显地改变生理性肾虚进程中的代谢物轨迹。结论生理性肾虚证是和多个代谢途径相关

补肾可能改善了部分代谢途径

代谢组学技术为生理性肾虚证的研究提供了新的手段和方法。

Abstract

Objective To observe the specific changes of urine metabolite in the process of physiological kidney deficiency and the effect of flavone of Herba Epimedii （EF） which functions to reinforce the kidney. Methods The urine of SD rats of 4

24 months old rats with EF interventionwere collected. The urine was examined by 1H nuclear magnetic resonance and the specific metabolite of physiological kidney deficiency syndrome was selected by T2 test and tendency filtration method. At the same time

the effect of EF on the metabolite was observed. Results The 34 spectrum peeks related to physiological kidney deficiency syndrome were selected and 13 metabolites were determined

finding that the significant difference of metabolism existed in the process of physiological kidney deficiency and EF could change the orbit of metabolites. Conclusion The physiological kidney deficiency syndrome is related with multiple metabolic ways

reinforcing the kidney may improve some of these metabolic ways. The metabonomic technique provides a new way for studying the physiological kidney deficiency syndrome.

关键词

Keywords

references

查看原文

Views

562

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Effect of Erzhi Pill （二至丸） of Different Dosing Time on the Expression of Biological Clock-related Factors Bmal1 and Cry1 in the Liver Tissue of Aging Liver Injury Model Mice

Effects of Guben Jiannao Anshen Formula （固本健脑安神方） on Learning and Memory Ability Hippocampal Clock and Bmal1 Genes Expression in Aging Insomnia Model Rats

Screening of Laboratory Medicine Indexes of Kidney Deficiency Syndrome

Differentiation and Analysis of “Deficiency”（虚）, “Damage”（损） and “Decline”（衰） in Traditional Chinese Medicine

Treating Chronic Infection of Hepatitis B Virus from Kidney Deficiency

Related Author

DUAN Lengxin

LI Sanqiang

FENG Menglin

WEI Xinyi

GONG Yuqing

MA Xiangyu

Lan HONG

Xi SHEN

Related Institution

School of Basic Medicine， Henan University of Science and Technology

Medical School， Hubei Minzu University

Hubei Provincial Key Laboratory of Occurrence and Intervention of Rheumatic Disease， Hubei Minzu University

Institute of Medical Technology,Chengdu University of Traditional Chinese Medicine

Pengzhou Hospital of Traditional Chinese Medicine

Address：No.16, Nanxiao street, Dongzhimen, Dongcheng District, Beijing Postal code：100700
Tel：010-64035632 Email：jtcmcn@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备09064830号-19 京公网安备11010102007558号
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰