Effect of Bushen Qiangji Granule on the Expression of CD4<sup>+</sup>T Lymphocyte Apoptosis Related Gene of Patients with Ankylosing Spondylitis

WANG Hailong; FENG Xinghua; JIANG Quan; et al.

doi:10.13288/j.11-2166/r.2009.09.009

您当前的位置：

首页 >

文章列表页 >

Effect of Bushen Qiangji Granule on the Expression of CD4⁺T Lymphocyte Apoptosis Related Gene of Patients with Ankylosing Spondylitis

更新时间：2021-11-17

- Effect of Bushen Qiangji Granule on the Expression of CD4⁺T Lymphocyte Apoptosis Related Gene of Patients with Ankylosing Spondylitis
- Journal of Traditional Chinese Medicine Vol. 50, Issue 9, Pages: 801-803(2009)
- 作者机构：
  
  中国中医科学院广安门医院风湿免疫科
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2009.09.009
  CLC： R259
- Published：2009
- 稿件说明：
移动端阅览
[1]王海隆,冯兴华,姜泉,张华东,何夏秀,唐晓颇,刘宏潇.补肾强脊颗粒对强直性脊柱炎患者外周血CD4~+T淋巴细胞凋亡相关基因表达的影响[J].中医杂志,2009,50(09):801-803.

WANG Hailong, FENG Xinghua, JIANG Quan, et al. Effect of Bushen Qiangji Granule on the Expression of CD4⁺T Lymphocyte Apoptosis Related Gene of Patients with Ankylosing Spondylitis[J]. Journal of Traditional Chinese Medicine2009, 50(9): 801-803. DOI: 10.13288/j.11-2166/r.2009.09.009.
[1]王海隆,冯兴华,姜泉,张华东,何夏秀,唐晓颇,刘宏潇.补肾强脊颗粒对强直性脊柱炎患者外周血CD4~+T淋巴细胞凋亡相关基因表达的影响[J].中医杂志,2009,50(09):801-803. DOI： 10.13288/j.11-2166/r.2009.09.009.

WANG Hailong, FENG Xinghua, JIANG Quan, et al. Effect of Bushen Qiangji Granule on the Expression of CD4⁺T Lymphocyte Apoptosis Related Gene of Patients with Ankylosing Spondylitis[J]. Journal of Traditional Chinese Medicine2009, 50(9): 801-803. DOI: 10.13288/j.11-2166/r.2009.09.009. DOI：

摘要

目的观察补肾强脊颗粒对强直性脊柱炎（AS）患者外周血CD4+T细胞的调节作用。方法将30例AS患者随机分为补肾强脊颗粒组和柳氮磺吡啶（SASP）组各15例

在治疗前和治疗后12周后分别采集两组患者外周血

分离CD4+T细胞

采用RT-PCR测定细胞凋亡相关基因Fas、FasL及Bcl-2、Bax mRNA的表达。结果补肾强脊颗粒可促进AS患者外周血CD4+T淋巴细胞Fas、FasL的表达（P<0.05或P<0.01）

而对Bcl-2、Bax的表达无明显影响。结论补肾强脊颗粒可能是通过Fas-FasL途径影响CD4+T细胞的激活诱导的细胞凋亡作用。

Abstract

Objective To study the effect of Bushen Qiangji Granule（Granule for reinforcing kidney to strengthen the spine） on CD4+T lymphocytes of peripheral blood in patients with ankylosing spondylitis（AS）.Methods Thirty AS patients were randomized into Bushen Qiangji Granule group and salicylazosulfapyridine（SASP） group with 15 in each.Before treatment and 12 weeks after treatment the peripheral blood CD4+T lymphocyte samples were collected and CD4+T lymphocytes were separated.The expression of Fas

FasL

Bcl-2 and Bax was detected by RT-PCR.Results Bushen Qiangji Granule promoted the expression of Fas and FasL（P<0.05 or P<0.01）

while the expression of Bcl-2 and Bax was not significantly affected.Conclusion Bushen Qiangji Granule induces apoptosis of CD4+T lymphocytes through affecting the expression of Fas-FasL.

关键词

Keywords

references

查看原文

Views

327

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

基于NLRP3/Caspase-1/IL-1β信号通路探讨通窍明目Ⅳ号方含药血清对L-谷氨酸诱导R28细胞损伤的影响

Effects of Bushen Tiaojing Formula （补肾调经方） on Blastocyst Cell Apoptosis and Endoplasmic Reticulum Stress in Repeated Controlled Ovarian Stimulation Model Mice

Effects of Jianpi Yishen Huatan Formula （健脾益肾化痰方）-Medicated Serum on Apoptosis，Migration and the LncRNA ALAL-1/USP4/HDAC2 Pathway in Human Lung Squamous Carcinoma Cells

The Effect of Zhiqiao Gancao Decoction （枳壳甘草汤） on Intervertebral Disc Nucleus Pulposus Cell Apoptosis and the Hippo-YAP/TAZ Signaling Pathway in Tail Intervertebral Disc Degeneration Model Rats

The Effect of Ziyin Mingmu Formula （滋阴明目方） on Retinal Tissue Apoptosis and Endoplasmic Reticulum Stress in Retinitis Pigmentosa Model Mice

Related Author

GAO Qing

SUN He

WANG Liyuan

PANG Qingbao

XIONG Wenyan

SHI Beibei

SHEN Lulu

DU Huilan

Related Institution

School of Life Sciences，Zhejiang Chinese Medical University

Heilongjiang University of Chinese Medicine

First Affiliated Hospital，Heilongjiang University of Chinese Medicine

School of Integrated Traditional Chinese and Western Medicine，Hebei University of Chinese Medicine

Collaborative Innovation Center for Reproductive Diseases of Integrated Traditional Chinese and Western Medicine in Hebei Province

Address：No.16, Nanxiao street, Dongzhimen, Dongcheng District, Beijing Postal code：100700
Tel：010-64035632 Email：jtcmcn@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备09064830号-19 京公网安备11010102007558号
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰

Effect of Bushen Qiangji Granule on the Expression of CD4+T Lymphocyte Apoptosis Related Gene of Patients with Ankylosing Spondylitis

DOI：10.13288/j.11-2166/r.2009.09.009

摘要

Abstract

关键词

Keywords

references

Effect of Bushen Qiangji Granule on the Expression of CD4⁺T Lymphocyte Apoptosis Related Gene of Patients with Ankylosing Spondylitis