Effects of Qingre Qushi Yiqi Formula on the Expressions of the Injured Hepatocyte Apoptosis Related Proteins in Mice

QING Hui; HUANG Xia; LIU Huixia; et al.

doi:10.13288/j.11-2166/r.2009.09.042

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Effects of Qingre Qushi Yiqi Formula on the Expressions of the Injured Hepatocyte Apoptosis Related Proteins in Mice

更新时间：2021-11-17

- Effects of Qingre Qushi Yiqi Formula on the Expressions of the Injured Hepatocyte Apoptosis Related Proteins in Mice
- Journal of Traditional Chinese Medicine Vol. 50, Issue 9, Pages: 839-841(2009)
- 作者机构：
  
  河南省中医药研究院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2009.09.042
  CLC： R285
- Published：2009
- 稿件说明：
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[1]庆慧,黄霞,刘惠霞,孙为.清热祛湿益气方对肝损伤细胞凋亡相关蛋白表达的影响[J].中医杂志,2009,50(09):839-841.

QING Hui, HUANG Xia, LIU Huixia, et al. Effects of Qingre Qushi Yiqi Formula on the Expressions of the Injured Hepatocyte Apoptosis Related Proteins in Mice[J]. Journal of Traditional Chinese Medicine2009, 50(9): 839-841.
[1]庆慧,黄霞,刘惠霞,孙为.清热祛湿益气方对肝损伤细胞凋亡相关蛋白表达的影响[J].中医杂志,2009,50(09):839-841. DOI： 10.13288/j.11-2166/r.2009.09.042.

QING Hui, HUANG Xia, LIU Huixia, et al. Effects of Qingre Qushi Yiqi Formula on the Expressions of the Injured Hepatocyte Apoptosis Related Proteins in Mice[J]. Journal of Traditional Chinese Medicine2009, 50(9): 839-841. DOI： 10.13288/j.11-2166/r.2009.09.042.

摘要

目的观察清热祛湿益气方对刀豆蛋白A（ConA）诱导的急性肝损伤模型小鼠肝细胞凋亡相关蛋白表达的影响。方法Balb/c雄性小鼠50只

随机分为空白组

模型组

清热祛湿益气方低、中、高剂量组

每组10只

连续灌胃7天。采用Con A诱导复制小鼠急性肝损伤病理模型

观察不同剂量清热祛湿益气方（7.5g/kg、10.0g/kg、12.5g/kg）对肝细胞Bax、Bcl-2以及Caspase-3 mR-NA表达的影响。结果与模型组比较

清热祛湿益气方不同剂量可下调模型小鼠肝组织Bax、Caspase-3 mRNA的表达

并可上调Bcl-2的表达（P<0.05）

随剂量增大

Bcl-2阳性率分别为17.56%、18.28%、26.36%。结论清热祛湿益气方可抑制肝细胞凋亡

对Con A诱导的急性肝损伤具有治疗作用。

Abstract

Objective To investigate the effects of Qingre Qushi Yiqi Formula（QQYF） on the expressions of the hepatocyte apoptosis proteins in acute hepatic injury of mice induced by concanavalin A（Con A）.Methods The pathologic model of acute hepatic injury induced by Con A was used for evaluating the therapeutic effects of QQYF in mice.The Balb/c mice were randomized into 5 groups: blank group

model group

the 7.5g/kg QQYF group

the 10.0g/kg QQYF group and the 12.5g/kg QQYF group.All preparations were administrated by intra-gastric infusion.After 7 days

the expression of the apoptosis proteins including bax

bc1-2 and caspase-3 mRNA were measured.Results Bax and Caspase-3 mRNA expression decreased and Bcl-2 expression increased(（P<0.05）after treatment by QQYF.With the dose of QQYF increased

Bcl-2 positive rates were 17.56

18.28

26.36.Conclusion QQYF could inhibit hepatocyte apoptosis

and has a protective effect on acute hepatic injury in mice induced by Con A.

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