Objective To set up and evaluate the anologous phlegm-heat syndrome models of bacterial pneumonia.Methods The bacterial pneumonia models were set up by bacteria instillation method through tracheal intubation

of them the phlegm heat syndrome models were made by giving wind heat stimulation in a hot environment.The rats were randomized into normal control group

pneumonia group

heat syndrome group

model group

recipe-manifestation corresponding group

and recipe-manifestation non-corresponding group

with 12 rats in each.The general state of rats and pathological injury of lung tissues were observed.Radioimmunoassay was used to detect the blood epinephrine（E）

norepinephrine（NE）

cortisol（Cor）

and the contents of TNF-α

IL-6 and intercellular adhesion molecule 1（ICAM-1） in the bronchoalveolar lavage fluid（BALF）.Results Compared with the normal control group

the blood E

NE

and Cor

and the contents of TNF-α

IL-6

and ICAM-1 in BALF of model group

heat syndrome group

pneumonia group

recipe-manifestation corresponding group

and recipe-manifestation non-corresponding group were all increased（P<0.05 or P<0.01）

with the most significant increase in the model group（P<0.01）.Compared with the model group

the blood E

NE

and Cor

and the contents of TNF-α

IL-6

and ICAM-1 in BALF of recipe-manifestation corresponding group and recipe-manifestation non-corresponding group were all decreased

with the most significant decrease in the recipe-manifestation corresponding group（P<0.05 or P<0.01）.Conclusion To adopt the method of TCM etiology in combination with disease model to set up the heat syndrome model of bacterial pneumonia is practical.