Objective To study the repairing mechanism of electroacupuncture on mucosal cells of rats with gastric mucosal damage.Methods The experimental rats were randomized into normal group

model group

and electroacupuncture group

10 in each.The models were created by gastric administration with ethanol.After electroacupuncture treatment for 10 days

the gastric mucosal cells were separated with pronase digestion method.The surface enhanced laser desorption ionization-time of flight-mass spectrometry（SELDI-TOF-MS） technique and WCX2 protein chip were applied to obtain the fingerprints of proteins of gastric mucosal cells of all groups.A contrastive analysis was carried out to see the difference in charge-to-mass ratio peaks of all groups.Results Compared with the normal group

the fingerprints of proteins of gastric mucosal cells in the model group had 4 charge-to-mass ratio peaks

the difference was significant（P<0.05 or P<0.01）

of which

two of the peaks were significantly elevated（P<0.05 or P<0.01）

and two significantly lowered（P<0.05）.Compared with the model group

the fingerprints of proteins of gastric mucosal cells in the electroacupuncture group had 4 charge-to-mass ratio peaks

the difference was significant（P<0.05 or P<0.01）

of which

one of the peaks was significantly elevated（P<0.05）

and three significantly lowered（P<0.05 or P<0.01）.Compared with the normal group

the fingerprints of proteins of gastric mucosal cells in the electroacupuncture group also had 4 charge-to-mass ratio peaks

the difference was significant（P<0.05 or P<0.01）

all of which were lowered（P<0.05 or P<0.01）.Conclusion The repairing of gastric mucosal cells by electroacupuncture is probably not aimed at regulating one or two proteins

but a complicated chain reaction joined by multiple proteins.