HU Kongyou, YU Linzhong. Effect of Lianggesan on T Helper Cell Shift in Rats with Acute Lung Injury Induced by Endotoxin[J]. Journal of Traditional Chinese Medicine2009, 50(11): 1023-1025.
HU Kongyou, YU Linzhong. Effect of Lianggesan on T Helper Cell Shift in Rats with Acute Lung Injury Induced by Endotoxin[J]. Journal of Traditional Chinese Medicine2009, 50(11): 1023-1025.DOI: 10.13288/j.11-2166/r.2009.11.037.
Effect of Lianggesan on T Helper Cell Shift in Rats with Acute Lung Injury Induced by Endotoxin
Objective To investigate the molecular mechanism of inflamation development and anti-inflamation response of Lianggesan Decoction(Decoction for cooling the chest) on endotoxin-induced acute lung injury rats. Methods The rat models with acute lung injury were made by lipopolysaccharide(LPS) through intravenous injection.The high
middle and low dosage of Lianggesan Decoction were given by gastric perfusion and compared with dexamethasone(DXM).The contents of Th1 and Th2 in peripheral blood and bronchoalveolar lavage fluid(BALF) were measured at different time points to observe the changes in Th1/Th2.Results In the model group
Th1/Th2 in peripheral blood and BALF was gradually lowering
the difference was significant compared with those of the blank group(P<0.01) at 4h
8h
16h.In the middle and high dosage groups and DXM group
Th1/Th2 was getting higher at 8h and 16h compared with that of the model group with a significant difference(P<0.05 or P<0.01).Conclusion Lianggesan Decoction corrects the Th1/Th2 imbalance
which might be one of the mechanisms in protecting the acute lung injury.
Effect of Qingfei Chengqi Decoction on Acute Lung Injury in Rats with Severe Abdominal Infection
Effect of Modified Jianpi Huashi Formula (健脾化湿方) on Rebleeding Rate within One Year and the Levels of Endotoxin and Cytokines in Patients with HBV-related Liver Cirrhosis and Esophageal Variceal Bleeding
Effect of Qingfei Litan Formula (清肺理痰方) on Lung Function, Lung Tissue Pathology and Inflammatory Factors in Klebsiella pneumoniae-induced Acute Lung Injury Model Mice
Effects of Pancreas-Clearing Toxin-Resolving Granules on the Contents of Endotoxin and Interleukin-6 in Rat Models with Severe Acute Pancreatitis
Impact of Yiqi Huayu Jiedu Formula (益气化瘀解毒复方) Combined with Ultra-low Frequency Electromagnetic Field Treated Water on Endotoxin Induced Acute Lung Injury in Rats
Related Author
ZHANG Shukun
CUI Naiqiang
ZHANG Yanmin
JI Xiaomin
SUN Le
WU Tong
MENG Peipei
YANG Yuying
Related Institution
Tianjin Nankai Hospital
Beijing Ditan Hospital, Capital Medical University
Shenzhen Research Institute of Beijing University of Chinese Medicine
School of Life Sciences, Beijing University of Chinese Medicine
The First Affiliated Hospital of Guangzhou Medical University