Effect of Sangjing Capsule on Antioxidant Capacity and Bax and Bcl-2 Expression in Type 2 Diabetic Rats

ZHANG Xin; LU Fuer; DAI Lian; et al.

doi:10.13288/j.11-2166/r.2009.12.043

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Effect of Sangjing Capsule on Antioxidant Capacity and Bax and Bcl-2 Expression in Type 2 Diabetic Rats

更新时间：2021-11-17

- Effect of Sangjing Capsule on Antioxidant Capacity and Bax and Bcl-2 Expression in Type 2 Diabetic Rats
- Journal of Traditional Chinese Medicine Vol. 50, Issue 12, Pages: 1117-1120(2009)
- 作者机构：
  
  华中科技大学同济医学院同济医院中西医结合研究所
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2009.12.043
  CLC： R285.5
- Published：2009
- 稿件说明：
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[1]张馨,陆付耳,代莲,徐丽君,董慧,杨明炜.桑精胶囊对2型糖尿病大鼠抗氧化能力及Bax、Bcl-2蛋白表达的影响[J].中医杂志,2009,50(12):1117-1120.

ZHANG Xin, LU Fuer, DAI Lian, et al. Effect of Sangjing Capsule on Antioxidant Capacity and Bax and Bcl-2 Expression in Type 2 Diabetic Rats[J]. Journal of Traditional Chinese Medicine2009, 50(12): 1117-1120.
[1]张馨,陆付耳,代莲,徐丽君,董慧,杨明炜.桑精胶囊对2型糖尿病大鼠抗氧化能力及Bax、Bcl-2蛋白表达的影响[J].中医杂志,2009,50(12):1117-1120. DOI： 10.13288/j.11-2166/r.2009.12.043.

ZHANG Xin, LU Fuer, DAI Lian, et al. Effect of Sangjing Capsule on Antioxidant Capacity and Bax and Bcl-2 Expression in Type 2 Diabetic Rats[J]. Journal of Traditional Chinese Medicine2009, 50(12): 1117-1120. DOI： 10.13288/j.11-2166/r.2009.12.043.

摘要

目的探讨桑精胶囊治疗2型糖尿病的分子机制。方法采用尾静脉注射小剂量链脲佐菌素加高脂高热量饮食喂养的方法建立2型糖尿病大鼠模型

将造模动物随机分为模型组、二甲双胍组和桑精胶囊组

另设正常组对照。药物干预8周后

检测各组大鼠抗氧化能力指标超氧化物歧化酶（SOD）、丙二醛（MDA）、谷胱甘肽过氧化物酶（GSH-Px）、一氧化氮（NO）等

同时采用免疫组化法检测胰腺Bax、Bcl-2蛋白表达水平。结果模型组大鼠抗氧化能力及Bax、Bcl-2蛋白表达与正常组比较差异均有统计学意义（P<0.05或P<0.01）;药物干预后

二甲双胍组、桑精胶囊组与模型组比较

SOD、GSH-Px、NO及Bax、Bcl-2蛋白表达均明显改善（P<0.05或P<0.01）

其中对SOD、GSH-Px的改善桑精胶囊组要优于二甲双胍组（P<0.01）。结论桑精胶囊对2型糖尿病的治疗效应可能与其改善2型糖尿病大鼠氧化应激和抑制胰岛β细胞凋亡有关。

Abstract

Objective To investigate the molecular mechanism of Sangjing Capsule （Mulberry capsule for diabetes） for type 2 diabetes.Methods The rat models of type 2 diabetes were established by intravenous injection of small dosage of streptozotocin plus high fat and high caloric diet.Then the animals were randomized into model group

metformin group and Sangjing Capsule group.A normal control group was set up for comparison.With medicinal intervention for eight weeks

the indices of antioxidant capacity including superoxide dismutase （SOD）

Malondialdehyde （MDA）

glutathion peroxidase （GSH-Px） and nitric oxide （NO） of all groups were examined

and the expression of Bax and Bcl-2 was tested with immunohistochemical method.Results In the model group

the antioxidant capacity and Bax and Bcl-2 expression were significantly different from those of the normal control group （P<0.05 or P<0.01）.After medicinal intervention

in the metformin group and Sangjing Capsule group

SOD

GSH-Px

NO and expression of Bax and Bcl-2 were all significantly improved as compared with the model group （P<0.05 or P<0.01）

and SOD as well as GSH-Px was more significantly improved in Sangjing Capsule group than in metformin group （P<0.01）.Conclusion The therapeutic effect of Sangjing Capsule on type 2 diabetes might be related to its ability of improving oxidative stress and inhibiting apoptosis of pancreas of rats.

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Related Institution

Changchun University of Chinese Medicine

Longhua Hospital, Shanghai University of Traditional Chinese Medicine/Institute of Spine Diseases, Shanghai University of Traditional Chinese Medicine

Department of Pediatrics，First Affiliated Hospital of Henan University of Chinese Medicine

College of Pediatrics，Henan University of Chinese Medicine

Children Hospital，First Affiliated Hospital of Henan University of Chinese Medicine

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