Objective To investigate the effect of Jingfukang Granule （Granule for cervical spondylosis） on the morphological changes of cervical intervertebral disc in rats with cervical intervertebral disc degeneration induced by unbalanced dynamic and static forces.Methods Male SD rats were randomly divided into control group

model group

Jingfukang Granule group

and Mobic group

12 rats in each group.The imbalance model of dynamic and static force of cervical intervertebral disc degeneration was established.The drugs were given after modeling

and the rats were sacrificed 4 weeks later.Four samples of cervical intervertebral disc were collected from each group and two sections in succession were used to observe the histopathological changes.The ratio of un-calcified layer to calcified layer in cartilage endplate

and the number and area of vascular bud were measured under light microscope.Expression of vascular endothelial growth factor （VEGF）

insulin-like growth factor-1 （IGF-1）

and transforming growth factor-β （TGF-β） were tested.Results Rats in the model group had degeneration in the cervical intervertebral disc

decrease of the number of vascular bud

and decrease of the ratio of un-calcified layer to calcified layer in cartilage endplate

increased VEGF expression

and decreased IGF-1 and TGF-β expressions （P<0.01）.Compared with the model group

the rats in the Jingfukang Granule group had increased number of vascular bud （P<0.01）;the rats in the Jingfukang Granule group and Mobic group had improved morphological structure （P<0.01 or P<0.05）

increased ratio of un-calcified layer to calcified layer in cartilage endplate （P<0.01）

down-regulated expression of VEGF

and up-regulated expression of IGF-1 and TGF-β （P<0.01）.Conclusion By regulating the expression of VEGF

IGF-1

and TGF-β

Jingfukang Granule could improve the morphological changes.With the decreased degradation of extracellular matrix

the degeneration of intervertebral disc could be delayed.