Effect of Zhimaikang Granules on Lipid Peroxidation of Hyperlipidemia Patients with Syndrome of Phlegm Turbidity Retention

LI Dianhong; JIN Lili; BIAN Jifang; LIANG Hongyu; HUANG Peihong; SU Hui

doi:10.13288/j.11-2166/r.2010.01.014

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Effect of Zhimaikang Granules on Lipid Peroxidation of Hyperlipidemia Patients with Syndrome of Phlegm Turbidity Retention

更新时间：2021-11-17

- Effect of Zhimaikang Granules on Lipid Peroxidation of Hyperlipidemia Patients with Syndrome of Phlegm Turbidity Retention
- Journal of Traditional Chinese Medicine Vol. 51, Issue 1, Pages: 34-36(2010)
- 作者机构：
  
  广东省第二中医院一内科
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2010.01.014
  CLC： R259
- Published：2010
- 稿件说明：
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[1]李典鸿,靳利利,卞继芳,梁宏宇,黄培红,苏慧.脂脉康颗粒对痰浊阻遏证高脂血症患者脂质过氧化的影响[J].中医杂志,2010,51(01):34-36.

LI Dianhong, JIN Lili, BIAN Jifang, et al. Effect of Zhimaikang Granules on Lipid Peroxidation of Hyperlipidemia Patients with Syndrome of Phlegm Turbidity Retention[J]. Journal of Traditional Chinese Medicine2010, 51(1): 34-36.
[1]李典鸿,靳利利,卞继芳,梁宏宇,黄培红,苏慧.脂脉康颗粒对痰浊阻遏证高脂血症患者脂质过氧化的影响[J].中医杂志,2010,51(01):34-36. DOI： 10.13288/j.11-2166/r.2010.01.014.

LI Dianhong, JIN Lili, BIAN Jifang, et al. Effect of Zhimaikang Granules on Lipid Peroxidation of Hyperlipidemia Patients with Syndrome of Phlegm Turbidity Retention[J]. Journal of Traditional Chinese Medicine2010, 51(1): 34-36. DOI： 10.13288/j.11-2166/r.2010.01.014.

摘要

目的观察脂脉康颗粒对高脂血症（痰浊阻遏证）患者的抗动脉粥样硬化作用。方法将120例高脂血症患者随机分为治疗组和对照组

每组60例。治疗组给予脂脉康颗粒

每次1袋

每日2次

饭前服用。对照组给予舒降之20mg

每晚临睡前口服。两组均以45天为1个疗程。观察患者超氧化物歧化酶（SOD）、丙二醛（MDA）、一氧化氮（NO）含量治疗前后变化。结果治疗组及对照组治疗后NO及血清SOD活性均较治疗前明显升高（P<0.01或P<0.05）

两组治疗后血清MDA的浓度均明显降低（P<0.01）。治疗组治疗后SOD、NO升高优于对照组

两组治疗后MDA水平差异无统计学意义（P>0.05）。结论脂脉康颗粒剂能提高抗氧化酶的活性

抗自由基反应

抑制脂质过氧化损伤

保护内皮细胞

而具有抗动脉粥样硬化作用。

Abstract

Objective To study the effect of Zhimaikang Granules （Granules for lipid abnormality） on atherosclerosis of hyperlipidemia patients of phlegm turbidity retention type.Methods Totally 120 hyperlipidemia patients were randomized into treatment group and control group

60 cases in each. The treatment group was administered Zhimaikang Granules

each time 1 bag

twice a day. The control group was given Simvastatin Tablets

oral taking before sleeping. Both groups were treated for 45 days. Changes of superoxide dismutase （SOD）

malondialdehyde （MDA）

and nitric oxide （NO） were observed.Results After treatment

activity of NO and SOD were significantly higher than before in both groups （P<0.01 or P<0.05） and MDA concentration was significantly reduced （P<0.01）. The increase of SOD activity and NO in the treatment group was more significant than that in the control group. The MDA level of both groups after treatment was not significant （P>0.05）.Conclusion Zhimaikang Granules was proved to enhance the activity of antioxidase

promote anti-free radical reactions

inhibit lipid peroxidation and protect endothelial cells in atherosclerosis patients.

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