Objective To explore the gene expression pattern of Baicalin and Jasminoidin

which are main ingredients of Qingkailing （Chinese medicine for clearing heat to restore consciousness）

and their combination in cerebral ischemia-reperfusion injury.Methods Twelve 4-week-old mice were randomized into Baicalin group （Group BA）

Jasminoidin group （Group JA）

Baicalin and Jasminoidin combination group （Group BJ）

Nimodipine group （Group NM）. After making models of whole brain ischemia and reperfusion

they were administered Baicalin

Jasminoidin

their combination

and Nimodipine respectively. Total RNA was obtained from brain tissue to prepare the whole gene profile for gene ontology classification by gene function to construct the related coefficient matrix to make a comparative analysis with the principal component analysis （PCA） on the cell adhesion genes of different expressions.Results The 16463 whole gene profiles were obtained

from which 32 cell adhesion-related genes of different expressions were selected. PCA showed that the accumulation contribution rate of top two principal components of the four groups was 100%. The total score of Group BJ was more than that of Group BA and Group JA respectively. The total score of Group NM was higher than that of group BA and JA. The distribution of principal components showed that there was a long distance between Group NM and the three Chinese medicine groups

and the distance from Groups BJ to BA was nearer than to group JA.Conclusion Baicalin and Jasminoidin can effectively intervene the adhesion-related genes. The effect on adhesion-related genes of the combination of the two is greater than the single component

and their expression pattern is similar to that of Baicalin.