Objective To investigate the mechanism of Qushi Huayu Decoction （Decoction for dissolving damp and removing stasis） in inhibiting the experimental free fatty acid expression based on ADP-FFA pathway.Methods SD male rats were used to establish fatty liver models by high-fat diet.At the beginning of the seventh week of modeling

21 rats were randomized into the model group

Qushi Huayu Decoction high-dose and low-dose groups

with 7 in each.They were given water or the decoction of different dosage by gavage for 4 weeks.Changes in triglyceride （TG） and Free Fatty Acid （FFA） in liver tissue

hepatic steatosis

serum adiponectin （ADP）

adiponectin receptor 2 （Adipo R2）

Adenosine Monophosphate-activated Protein Kinase （AMPK）

fatty acid synthase （FAS）

Acetyl-Coenzyme A Carboxylase （ACCase）

and malonyl coenzyme A （Malonyl-CoA） in liver tissue were observed

and were compared with those of the normal group.Results Compared with the model group

TG and FFA

FAS

ACCase

and Malonyl-CoA in liver tissue of Qushi Huayu Decoction high-dose and low-dose groups were reduced significantly （P<0.01 or P<0.05）

while the Adipo R2 and AMPK in liver tissue and ADP in serum were increased markedly

showing a dose-effect relationship （P<0.05 or P<0.01）.Conclusion Qushi Huayu Decoction has a good effect on the FFA metabolism through the ADP-FFA pathway.Improving serum ADP and hepatic Adipo R2 levels significantly is one of its important mechanisms in inhibiting hepatic FFA so as to reduce hepatic lipid deposited.